microsomal glutathione S-transferase-I

catalyzes the conjugation of the tripeptide glutathione to a variety of electrophilic compounds and is part of the phase II hepatic detoxification system; amino acid sequence in first source; GenBank AB000884 (pig), W85543 (mouse) and AF111426 (Drosophila)

Also Known As:

Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shao, Yongfu: 1 article (04/2022)
2.	Yan, Jianing: 1 article (04/2022)
3.	Ye, Guoliang: 1 article (04/2022)
4.	Anandhan, Annadurai: 1 article (01/2021)
5.	Dodson, Matthew: 1 article (01/2021)
6.	Zhang, Donna D: 1 article (01/2021)
7.	Fu, Qiaofen: 1 article (01/2020)
8.	Ge, Chunlei: 1 article (01/2020)
9.	Guo, Huan: 1 article (01/2020)
10.	He, Juan: 1 article (01/2020)

Related Diseases

1.	Exfoliation Syndrome 03/01/2017 - "Immunohistochemical analysis of microsomal glutathione S-transferase 1 and clusterin expression in lens epithelial cells of patients with pseudoexfoliation syndrome." 01/01/2013 - "The aim of the study was to investigate the expression of selected genes encoding enzymes involved in the antioxidant defense system (superoxide dismutase 2, SOD2; aldehyde dehydrogenase 1, ALDH1A1; microsomal glutathione S-transferase 1, MGST1) in fragments of anterior lens capsules of patients with pseudoexfoliation syndrome (PEX). "
2.	Carcinoma (Carcinomatosis) 01/01/2023 - "In this study, we aimed to investigate how microsomal glutathione S-transferase 1 (MGST1) regulates ferroptosis in gastric carcinoma cells. " 01/01/2023 - "Microsomal glutathione S-transferase 1 targets the autophagy signaling pathway to suppress ferroptosis in gastric carcinoma cells."
3.	Neoplasms (Cancer) 01/01/2020 - "Microsomal glutathione S-transferase 1 (MGST1) has been reported to play vital roles in oxidative stress, tumor occurrence and drug resistance. " 10/13/2022 - "Here, we show that human MDA-B02 breast cancer cells produce CysLT through mechanisms involving microsomal glutathione-S-transferase 1/2/3 (MGST1/2/3) and that can modulate cancer cell-platelet interactions via platelet-CysLT1R. " 04/01/2022 - "MGST1 (microsomal glutathione S-transferase 1) involves in the regulation of oxidative stress and plays a key role in inhibiting iron-mediated cell death in cancer cells. " 01/01/2007 - "To explore the possible association between activation of rat microsomal glutathione S-transferase 1 (mGST1) and chlorambucil toxicity on selected cancer cell lines. " 05/10/2005 - "Western blot analyses confirmed that several of these proteins were elevated in the lung tumors and immunohistochemical analyses identified 3 proteins, microsomal glutathione-S-transferase 1 (Mgst1), cathepsin H and syndecan 1 as being consistently elevated in the murine lung tumors compared to non-tumor bearing transgenic lung tissue and normal lung tissue surrounding the tumor. "
4.	Hyperoxia 03/15/2013 - "Exposure of newborn WT mice to hyperoxia resulted in increased protein, enzyme and mRNA expression of the AhR-regulated lung cytochrome P450 1A1, NAD(P)H quinone oxidoreductase-1, and microsomal glutathione S-transferase 1 enzymes, suggesting that hyperoxia increases activation of the pulmonary AhR. "
5.	Teratocarcinoma 03/10/2003 - "These data were obtained with RNA probes pooled from several BCC of different donors and were subsequently confirmed by semiquantitative RT-PCR for Janus protein tyrosine kinase 3 (Jak3), microsomal glutathione S-transferase 1 (GST 12), teratocarcinoma-derived growth factor cripto, glutaredoxin and the monocyte chemoattractant protein 1 (MCP-1) in 10 individual BCC specimens, 2 squamous cell carcinoma (SCC), the cell line HaCaT and cultured normal human keratinocytes (NHK) in comparison to normal skin. "

Related Drugs and Biologics

1.	Enzymes
2.	Antioxidants
3.	Aldehyde Dehydrogenase 1 Family
4.	superoxide dismutase 2
5.	Proteins (Proteins, Gene)
6.	Cathepsin H
7.	Glutaredoxins
8.	Syndecan-1 (Syndecan 1)
9.	Caspase 3 (Caspase-3)
10.	Clusterin