|1.||Weiss, Robert M: 2 articles (06/2005 - 08/2004)|
|2.||Christensen, Lance P: 2 articles (06/2005 - 08/2004)|
|3.||Tomanek, Robert J: 2 articles (06/2005 - 08/2004)|
|4.||Dedkov, Eduard I: 1 article (06/2005)|
|5.||Brown, M D: 1 article (01/2005)|
|6.||Hudlicka, O: 1 article (01/2005)|
|7.||Davies, M K: 1 article (01/2005)|
|8.||Lei, Li: 1 article (08/2004)|
|9.||Zhou, Ruifeng: 1 article (08/2004)|
|10.||Zheng, Wei: 1 article (08/2004)|
07/01/1986 - "These results suggest that if prolongation of action potential duration by sustained beta blockade in patients after myocardial infarction contributes to protection against sudden death (by a class III antiarrhythmic action) then alinidine would not be expected to provide a comparable prophylaxis."
12/01/1987 - "There were 7 drop outs during treatment with ST 567:2 cases of myocardial infarction, exacerbation of angina in 2 patients, visual disturbances in 2 patients, vertigo in 1 patient. "
12/01/1987 - "Alinidine appears to be a safe drug for reduction of heart rate in patients with unstable angina and acute myocardial infarction. "
12/01/1987 - "Furthermore, alinidine was administered in 32 patients with acute myocardial infarction, 23 of these suffered from heart failure. "
12/01/1987 - "Effect of ST-567 (a specific bradycardiac agent) in patients with unstable angina and myocardial infarction."
01/01/2005 - "Angiogenesis and improved left ventricular function as a consequence of long-term bradycardia were first demonstrated in normal hearts, either electrically paced (rabbits, pigs) or treated with a selective sinus blocking drug alinidine (rats). "
05/01/1986 - "In this study, in the presence of caesium, which blocks the time dependent inward current activated by hyperpolarisation (ih or if), alinidine still caused a concentration related bradycardia in the rabbit sinoatrial node. "
05/01/1986 - "Further studies of alinidine induced bradycardia in the presence of caesium."
11/01/1989 - "On the other hand, alinidine, at doses which caused a depressor action and bradycardia in the intact dog, consistently produced negative chronotropic and inotropic effects in the isolated atrium. "
06/01/1989 - "These results show that the initial atrial cardioacceleration due to alinidine results from a direct vagolytic action of this drug and that the absence of atrial bradycardia results from buffering by the vagolytic effect and/or a relatively low basal atrial rate. "
12/01/1987 - "The purpose of the study was to investigate the prophylactic antiarrhythmic properties of alinidine on supraventricular tachyarrhythmias (svt), which occur with incidence after open heart surgery. "
01/01/1983 - "Alinidine did not change heart rate at rest in the healthy volunteers but it did significantly reduce exercise-induced tachycardia, whereas blood pressure and plasma catecholamine levels were not significantly affected by alinidine, either at rest or during exercise. "
03/01/1982 - "Exercise tachycardia was reduced by the three doses (20, 40 and 80 mg) of alinidine, and supine and standing heart rate by 80 mg alinidine. "
01/01/1982 - "Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. "
03/01/1982 - "The effects of the oral administration of alinidine (ST567) were studied on heart rate and blood pressure in healthy subjects in the supine and standing positions and on an exercise tachycardia. "
|4.||Septic Shock (Toxic Shock Syndrome)
08/01/1992 - "The present study explored the hemodynamic and gasometric effects of alinidine during dobutamine administration in a canine model of septic shock induced by endotoxin administration. "
08/01/1992 - "Addition of alinidine, a specific bradycardic agent, to dobutamine in a canine model of endotoxic shock."
08/01/1992 - "During experimental septic shock, alinidine administration can reverse dobutamine-induced tachycardia and simultaneously improve ventricular function."
08/01/1992 - "On the other hand, one limitation of the use of catecholamines is tachycardia, and alinidine could be beneficial in situations such as septic shock, where adrenergic agents are commonly required. "
09/01/1989 - "Dogs in which PES resulted in a reproducible nonsustained or sustained ventricular tachycardia (VT) were randomized to receive either intravenous alinidine (1 mg/kg, n = 11) or intravenous vehicle (n = 10). "
08/01/1995 - "Alinidine prevented reinduction of sustained ventricular tachycardia (SVT) in only 2 of 9 dogs and zatebradine in 1 of 8 dogs. "
03/01/1982 - "In ouabain-induced ventricular tachycardia, a cumulative dose of alinidine (15.5 mg/kg) reduced the number of ventricular beats by 91.6 +/- 1.9%. "
03/01/1982 - "The drug was much less effective in abolishing the ventricular tachycardia 24 h after ligation of a coronary artery, with only a 36 +/- 15% reduction in ventricular ectopic beats after 15.5 mg/kg. The administration of alinidine (0.5-1.0 mg/kg) to anaesthetized dogs with no cardiac arrhythmia reduced sinus node rate with little effect on the response of the node to vagal stimulation."
|2.||Adrenergic Agents (Adrenergic Drugs)
|6.||Calcium Channels (Calcium Channel)
|10.||Clonidine (ST 155)