The effect of alinidine (St 567) on emotionally induced tachycardia in man.

Abstract

Experiments were performed in a randomized double-blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally-induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine.

• Authors: J Auböck, H Konzett, E Olbrich
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 21 Issue 6 Pg. 467-71 ( 1982) ISSN: 0031-6970 [Print] Germany
• PMID: 7075652 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• alinidine
• Clonidine

Topics

• Adult
• Blood Pressure (drug effects)
• Clonidine (analogs & derivatives, therapeutic use)
• Drug Evaluation
• Heart Rate (drug effects)
• Humans
• Male
• Stress, Psychological (complications)
• Tachycardia (drug therapy, etiology)