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RO5256390

Also Known As:

(S)-4-((S)-2-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - RO5256390: 3

Experts

1.	Domith, Ivan: 1 article (01/2022)
2.	Lourenco, Mychael V: 1 article (01/2022)
3.	Paes-de-Carvalho, Roberto: 1 article (01/2022)
4.	Pandolfo, Pablo: 1 article (01/2022)
5.	Raony, Ícaro: 1 article (01/2022)
6.	Li, Jun-Xu: 1 article (12/2021)
7.	Wu, Ruyan: 1 article (12/2021)
8.	Black, Sarah W: 1 article (11/2017)
9.	Chen, Tsui-Ming: 1 article (11/2017)
10.	Hoener, Marius C: 1 article (11/2017)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 12/01/2021 - "Selective and potent engineered TAAR1 ligands, including full (RO5166017 and RO5256390) and partial (RO5203648, RO5263397 and RO5073012) agonists and the antagonist EPPTB (N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl) benzamide, RO5212773), serve as invaluable tools for the investigation of TAAR1 functions and display significant potential for the development of TAAR1-based pharmacotherapies for the treatment of substance use disorders. "
2.	Narcolepsy 11/01/2017 - "In the second experiment, the effects of the TAAR1 full agonist RO5256390 and partial agonist RO5263397 on sleep/wake, locomotor activity, body temperature, and cataplexy were assessed in two mouse narcolepsy models. "
3.	Hyperkinesis 01/01/2022 - "While intracerebroventricular (i.c.v.) administration of the selective TAAR1 antagonist EPPTB impaired cognitive performance in SHR, i.c.v. administration of highly selective TAAR1 full agonist RO5256390 decreased motor hyperactivity, novelty-induced locomotion, and induced an anxiolytic-like behavior. "
4.	Cataplexy 11/01/2017 - "In the second experiment, the effects of the TAAR1 full agonist RO5256390 and partial agonist RO5263397 on sleep/wake, locomotor activity, body temperature, and cataplexy were assessed in two mouse narcolepsy models. "

Related Drugs and Biologics

1.	4- (3- fluoro- 2- methylphenyl)- 4,5- dihydrooxazol- 2- ylamine
2.	Anti-Anxiety Agents (Anxiolytics)
3.	Ligands
4.	RO5166017
5.	4- (3,4- dichlorophenyl)- 4,5- dihydrooxazol- 2- ylamine
6.	(4- chlorophenyl)- (1H- imidazol- 4- ylmethyl)- isopropyl- amine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)