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MONIRO-1

Also Known As:

N-(2-(4-fluorophenoxy)phenyl)-4-(3-guanidinopropoxy)benzamide hydrochloride

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Anilides: 22
      - MONIRO-1: 2
- Amides: 2428
  - Anilides: 22
    - MONIRO-1: 2

Experts

1.	Duggan, Peter J: 2 articles (01/2020 - 01/2018)
2.	Lewis, Richard J: 2 articles (01/2020 - 01/2018)
3.	Tuck, Kellie L: 2 articles (01/2020 - 01/2018)
4.	Bispat, Anjie: 1 article (01/2020)
5.	Cardoso, Fernanda C: 1 article (01/2020)
6.	Geoffroy, Chloe: 1 article (01/2020)
7.	Marliac, Marie-Adeline: 1 article (01/2020)
8.	Schmit, Matthieu: 1 article (01/2020)
9.	Adams, David J: 1 article (01/2018)
10.	Gleeson, Ellen C: 1 article (01/2018)

Related Diseases

1.	Neuroblastoma 01/01/2020 - "Structural modifications of the neuronal calcium channel blocker MONIRO-1, including constraining the phenoxyaniline portion of the molecule and replacing the guanidinium functionality with tertiary amines, led to compounds with significantly improved affinities for the endogenously expressed CaV2.2 channel in the SH-SY5Y neuroblastoma cell line. "
2.	Pain (Aches) 01/01/2018 - "Selectivity, potency, reversibility and multi-modal effects distinguish MONIRO-1 from other low MW inhibitors acting on Cav channels involved in pain and/or epilepsy pathways. "
3.	Epilepsy (Aura) 01/01/2018 - "Selectivity, potency, reversibility and multi-modal effects distinguish MONIRO-1 from other low MW inhibitors acting on Cav channels involved in pain and/or epilepsy pathways. "

Related Drugs and Biologics

1.	Guanidine (Guanidine Nitrate)
2.	Calcium Channel Blockers (Blockers, Calcium Channel)
3.	Amines