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BLU-5937

selective P2X3 antagonist

Also Known As:

Methyl (S)-3-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo(1,2-a)pyridin-3-yl)methyl)piperidine-1-carboxylate

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds

Experts

1.	Buccioni, Michela: 1 article (12/2019)
2.	Dal Ben, Diego: 1 article (12/2019)
3.	Lambertucci, Catia: 1 article (12/2019)
4.	Martí Navia, Aleix: 1 article (12/2019)
5.	Marucci, Gabriella: 1 article (12/2019)
6.	Spinaci, Andrea: 1 article (12/2019)
7.	Volpini, Rosaria: 1 article (12/2019)
8.	Chauret, Nathalie: 1 article (01/2019)
9.	Garceau, Denis: 1 article (01/2019)

Related Diseases

1.	Chronic Cough 01/01/2019 - "In conclusion, BLU-5937 was selected as a drug candidate for the treatment of chronic cough due to its high potency and selectivity for P2X3 homotrimeric receptors, strong anti-tussive effects, excellent tolerability and predicted pharmacokinetic properties in humans." 01/01/2019 - "BLU-5937 is being developed for the treatment of unexplained, refractory chronic cough. " 01/01/2019 - "By inhibiting P2X3 receptors on the primary sensory neurons, BLU-5937 would inhibit the hypersensitization of the cough reflex and, hence, the exaggerated cough experienced in chronic cough patients. " 12/01/2019 - "The most promising compounds are the phenoxy-diaminopyrimidines including gefapixant (AF-219), and the imidazo-pyridines like BLU-5937, which are in phase III and phase II clinical trials, respectively, for refractory chronic cough."
2.	Ganglion Cysts (Ganglion) 01/01/2019 - "Furthermore, BLU-5937 (500 nM) was able to block αβ-meATP-induced sensitization and firing activity of isolated primary nociceptors in rat dorsal root ganglions (DRGs), through P2X3 homotrimeric receptor antagonism. "
3.	Cough 01/01/2019 - "By inhibiting P2X3 receptors on the primary sensory neurons, BLU-5937 would inhibit the hypersensitization of the cough reflex and, hence, the exaggerated cough experienced in chronic cough patients. " 01/01/2019 - "BLU-5937 (3 and 30 mg/kg, oral) was also shown to reduce significantly and dose-dependently the ATP-induced enhancement of citric acid-induced coughs in the guinea pig. " 01/01/2019 - "In a guinea pig cough model, BLU-5937 (0.3, 3 and 30 mg/kg, oral) significantly reduced, in a dose-dependent fashion, the histamine-induced enhancement in the number of citric acid-induced coughs. "

Related Drugs and Biologics

1.	Pyridines
2.	Gefapixant
3.	Citric Acid (Citrate)
4.	Histamine (Histamine Dihydrochloride)
5.	Adenosine Triphosphate (ATP)