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dichloro(phenanthroline)gold(III)

inhibits aquaglyceroporin-3; structure in first source

Also Known As:

(Au(phen)Cl2)Cl; Auphen

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organogold Compounds
    - dichloro(phenanthroline)gold(III): 4

Experts

1.	Li, J: 1 article (07/2016)
2.	Peng, R: 1 article (07/2016)
3.	Shen, X Z: 1 article (07/2016)
4.	Sun, J Y: 1 article (07/2016)
5.	Wang, J Y: 1 article (07/2016)
6.	Zhang, Y: 1 article (07/2016)
7.	Zhao, G X: 1 article (07/2016)
8.	Li, Jing: 1 article (03/2016)
9.	Peng, Rui: 1 article (03/2016)
10.	Shen, Xi-Zhong: 1 article (03/2016)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2016 - "We found that compared to HL-7702 (L02) liver cells, Auphen increased AQP3 expression in tumor cells, whereas dbcAMP decreased expression of AQP9 in these cells. " 03/28/2016 - "The reduction of AQP3 by Auphen and increase of AQP9 by dbcAMP in nude mice suppressed tumor growth of HCC, which resulted in reduced AFP levels in serum and tissues, and apoptosis of tumor cells in the Auphen- and dbcAMP-treated mice, when compared with control mice (P < 0.01). " 03/28/2016 - "The volumes and weights of tumors decreased significantly in the Auphen- and dbcAMP-treated mice compared with the control mice (P < 0.01). " 11/01/2022 - "In a breast cancer mouse model, Auphen@pOMPC-Dex markedly reduced the number of lung metastases in tumor-bearing mice due to the combined suppression of tumor growth and metastasis. "
2.	Hepatocellular Carcinoma (Hepatoma) 03/28/2016 - "Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo." 07/01/2016 - "Differential regulation of the expression of aquaporins 3 and 9 by Auphen and dbcAMP in the SMMC-7721 hepatocellular carcinoma cell line."
3.	Carcinogenesis 03/28/2016 - "To investigate whether the regulation of aquaporin 3 (AQP3) and AQP9 induced by Auphen and dibutyryl cAMP (dbcAMP) inhibits hepatic tumorigenesis. "
4.	Neoplasm Metastasis (Metastasis) 11/01/2022 - "In a breast cancer mouse model, Auphen@pOMPC-Dex markedly reduced the number of lung metastases in tumor-bearing mice due to the combined suppression of tumor growth and metastasis. "
5.	Carcinoma (Carcinomatosis) 11/01/2014 - "These results highlight an Auphen inhibitory effect on proliferation of cells expressing AQP3 and suggest a targeted therapeutic effect on carcinomas with large AQP3 expression."

Related Drugs and Biologics

1.	Aquaporins (Water Channels)
2.	Bucladesine
3.	Aquaporin 3
4.	Therapeutic Uses