brilacidin

a DEFENSIN mimetic with anti-infective activity

Also Known As:

N4,N6-bis(3-((5-(carbamimidoylamino)pentanoyl)amino(-2-((3R)-pyrrolidin-3-yloxy)-5-(trifluoromethyl)phenyl)pyrimidine-4,6-dicarboxamide; PMX 30063; PMX-30063; PMX-30063 free base; PMX30063; PMX30063 free base; brilacidin tetrahydrochloride

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - brilacidin: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - brilacidin: 4

Experts

1.	Chang, Theresa L: 1 article (04/2022)
2.	Harness, Jane A: 1 article (04/2022)
3.	Honnen, William: 1 article (04/2022)
4.	Narayanan, Aarthi: 1 article (04/2022)
5.	Pinter, Abraham: 1 article (04/2022)
6.	Wang, Annie: 1 article (04/2022)
7.	Weston, Warren K: 1 article (04/2022)
8.	Xu, Chuan: 1 article (04/2022)
9.	DeGrado, William F: 1 article (01/2022)
10.	Hu, Yanmei: 1 article (01/2022)

Related Diseases

1.	Infections 01/01/2017 - "The lead compound from this approach, brilacidin, has completed two phase 2 studies as an intravenous agent for skin infections."
2.	COVID-19 04/01/2022 - "Taken together, brilacidin inhibits SARS-CoV-2 infection by blocking viral entry and is active against SARS-CoV-2 variants." 04/01/2022 - "Brilacidin blocked SARS-CoV-2 infection but had no effect after viral entry. " 01/01/2022 - "Brilacidin, a COVID-19 drug candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell." 04/01/2022 - "Brilacidin, a Non-Peptide Defensin-Mimetic Molecule, Inhibits SARS-CoV-2 Infection by Blocking Viral Entry."
3.	Virus Diseases (Viral Diseases) 04/01/2022 - "Brilacidin (PMX-30063), a non-peptide defensin-mimetic small molecule, inhibits SARS-CoV-2 viral infection but the anti-viral mechanism is not defined. "
4.	Malaria 10/17/2023 - "Using different screening methods, eight compounds (Hayatinine, Curine, MMV689758 (Bedaquiline), MMV1634402 (Brilacidin), and MMV688271, MMV782353, MMV642550, and USINB4-124-8) were identified, which showed promising binding affinity (KD < 75 μM), along with submicromolar range antiparasitic efficacy and selectivity index > 100 fold for malaria parasite. "

Related Drugs and Biologics

1.	Defensins
2.	Peptides (Polypeptides)
3.	Antiviral Agents (Antivirals)
4.	Antiparasitic Agents (Antiparasitics)
5.	bedaquiline (R207910)
6.	curine