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MOC31PE immunotoxin

reduces cell migration and induces gene expression and cell death in ovarian cancer cells

Networked: 5 relevant articles (1 outcomes, 3 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Andersson, Yvonne: 5 articles (01/2021 - 09/2013)
2.	Flatmark, Kjersti: 5 articles (01/2021 - 09/2013)
3.	Fodstad, Øystein: 4 articles (01/2021 - 09/2013)
4.	Davidson, Ben: 3 articles (01/2021 - 07/2017)
5.	Dueland, Svein: 2 articles (01/2021 - 07/2017)
6.	Frøysnes, Ida S: 2 articles (01/2021 - 07/2017)
7.	Julsrud, Lars: 2 articles (01/2021 - 07/2017)
8.	Larsen, Stein G: 2 articles (01/2021 - 07/2017)
9.	Øien, Janne-Merete Torset: 2 articles (01/2021 - 07/2017)
10.	Fleten, Karianne G: 2 articles (09/2017 - 09/2013)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 07/01/2017 - "Novel Treatment with Intraperitoneal MOC31PE Immunotoxin in Colorectal Peritoneal Metastasis: Results From the ImmunoPeCa Phase 1 Trial." 01/01/2021 - "ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis." 01/01/2021 - "The ImmunoPeCa trial investigated the use of intraperitoneal MOC31PE immunotoxin as a novel therapeutic principle for the treatment of peritoneal metastasis from colorectal cancer (PM-CRC). " 09/22/2017 - "MOC31PE immunotoxin - targeting peritoneal metastasis from epithelial ovarian cancer."
2.	Neoplasms (Cancer) 09/22/2017 - "The MOC31PE immunotoxin targets and kills tumor cells expressing the epithelial cell adhesion molecule (EpCAM), which is highly expressed in EOC, and MOC31PE is being investigated for use in treatment of PM-EOC. " 07/01/2017 - "MOC31PE immunotoxin was developed to rapidly kill cells expressing the tumor-associated epithelial cell adhesion molecule, which is highly expressed in colorectal cancer. " 09/15/2013 - "The MOC31PE immunotoxin targets the tumor-associated adhesion protein EpCAM (Epithelial Cell Adhesion Molecule), and has been administered safely in early clinical trials. " 02/15/2014 - "The MOC31PE immunotoxin binds to the cell surface antigen EpCAM, which is expressed by the majority of epithelial cancers including ovarian carcinomas, and we studied the cytotoxic effects of MOC31PE in ovarian cancer cells. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2021 - "The ImmunoPeCa trial investigated the use of intraperitoneal MOC31PE immunotoxin as a novel therapeutic principle for the treatment of peritoneal metastasis from colorectal cancer (PM-CRC). " 07/01/2017 - "MOC31PE immunotoxin was developed to rapidly kill cells expressing the tumor-associated epithelial cell adhesion molecule, which is highly expressed in colorectal cancer. "
4.	Ovarian Neoplasms (Ovarian Cancer) 02/15/2014 - "The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells." 02/15/2014 - "The MOC31PE immunotoxin binds to the cell surface antigen EpCAM, which is expressed by the majority of epithelial cancers including ovarian carcinomas, and we studied the cytotoxic effects of MOC31PE in ovarian cancer cells. "
5.	Carcinoma (Carcinomatosis) 02/15/2014 - "The MOC31PE immunotoxin binds to the cell surface antigen EpCAM, which is expressed by the majority of epithelial cancers including ovarian carcinomas, and we studied the cytotoxic effects of MOC31PE in ovarian cancer cells. "

Related Drugs and Biologics

1.	Epithelial Cell Adhesion Molecule
2.	Proteins (Proteins, Gene)
3.	Surface Antigens (Surface Antigen)