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ethylsmenoquinone

has antineoplastic activity; structure in first source

Also Known As:

smenorthoquinone

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - ethylsmenoquinone: 2
- Quinones: 434
  - Benzoquinones: 25
    - ethylsmenoquinone: 2

Experts

1.	Hwang, In Hyun: 2 articles (01/2015 - 05/2014)
2.	Kim, Dong-Eun: 2 articles (01/2015 - 05/2014)
3.	Na, MinKyun: 2 articles (01/2015 - 05/2014)
4.	Oh, Sangtaek: 2 articles (01/2015 - 05/2014)
5.	Park, Seoyoung: 2 articles (01/2015 - 05/2014)
6.	Song, Gyu-Yong: 2 articles (01/2015 - 05/2014)
7.	Yun, Eunju: 2 articles (01/2015 - 05/2014)
8.	Chung, Kyu Jin: 1 article (01/2015)
9.	Chung, Young-Hwa: 1 article (01/2015)
10.	Gwak, Jungsuk: 1 article (01/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/16/2015 - "Our findings suggest that ilimaquinone and ethylsmenoquinone exert their anti-cancer activity by activation of the p53 pathway and may have significant potential as chemo-preventive and therapeutic agents for human colon cancer. " 05/28/2014 - "These findings suggest that ilimaquinone and ethylsmenoquinone exert their anti-cancer activity by blocking the Wnt/β-catenin pathway and have significant potential as therapies for multiple myeloma. "
2.	Multiple Myeloma 05/28/2014 - "Degradation of β-catenin was consistently found in RPMI-8226 multiple myeloma cells after ilimaquinone and ethylsmenoquinone treatment. " 05/28/2014 - "Ilimaquinone and ethylsmenoquinone, marine sponge metabolites, suppress the proliferation of multiple myeloma cells by down-regulating the level of β-catenin." 05/28/2014 - "These findings suggest that ilimaquinone and ethylsmenoquinone exert their anti-cancer activity by blocking the Wnt/β-catenin pathway and have significant potential as therapies for multiple myeloma. " 05/28/2014 - "Ilimaquinone and ethylsmenoquinone repressed the expression of cyclin D1, c-myc, and axin-2, which are β-catenin/T-cell factor-dependent genes, and inhibited the proliferation of multiple myeloma cells. "
3.	Colonic Neoplasms (Colon Cancer) 01/16/2015 - "Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells." 01/16/2015 - "Our findings suggest that ilimaquinone and ethylsmenoquinone exert their anti-cancer activity by activation of the p53 pathway and may have significant potential as chemo-preventive and therapeutic agents for human colon cancer. " 01/16/2015 - "We demonstrated that ilimaquinone and ethylsmenoquinone efficiently stabilize the p53 protein through promotion of p53 phosphorylation at Ser15 in both HCT116 and RKO colon cancer cells. "

Related Drugs and Biologics

1.	ilimaquinone
2.	TCF Transcription Factors
3.	Catenins
4.	Cyclin D1
5.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics