methoxy poly(ethylene glycol)- poly(epsilon- caprolactone)- methoxy poly(ethylene glycol)

a drug carrier

Also Known As:

MPEG-PCL-MPEG

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol): 3
  - Polyesters: 921
    - methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol): 3
Biomedical and Dental Materials
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol): 3
  - Polyesters: 921
    - methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol): 3
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomedical and Dental Materials
    - Polymers: 13051
      - Polyethylene Glycols: 3865
        methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol): 3
      - Polyesters: 921
        methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol): 3
Organic Chemicals: 133
- Alcohols: 595
  - Glycols: 38
    - Ethylene Glycols: 8
      - Polyethylene Glycols: 3865
        methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol): 3

Experts

1.	Atilla, Bülent: 1 article (10/2014)
2.	Batu, Ezgi Deniz: 1 article (10/2014)
3.	Erdemli, Özge: 1 article (10/2014)
4.	Keskin, Dilek: 1 article (10/2014)
5.	Tezcaner, Ayşen: 1 article (10/2014)
6.	Usanmaz, Ali: 1 article (10/2014)
7.	Özen, Seza: 1 article (10/2014)
8.	Akiyama, Fuminari: 1 article (10/2012)
9.	Kanazawa, Takanori: 1 article (10/2012)
10.	Okada, Hiroaki: 1 article (10/2012)

Related Diseases

1.	Myocardial Infarction 10/01/2009 - "Bone marrow stem cells implantation with alpha-cyclodextrin/MPEG-PCL-MPEG hydrogel improves cardiac function after myocardial infarction." 10/01/2009 - "This study indicated that the injection of BMSCs with alpha-cyclodextrin/MPEG-PCL-MPEG hydrogel was an effective strategy which could enhance the effect of cellular transplantation therapy for myocardial infarction."
2.	Infarction (Infarctions) 10/01/2009 - "This study was designed to investigate whether injectable alpha-cyclodextrin/poly(ethylene glycol)-b-polycaprolactone-(dodecanedioic acid)-polycaprolactone-poly(ethylene glycol) (MPEG-PCL-MPEG) hydrogel could improve cell transplant retention and survival, reduce infarct expansion and inhibit left ventricle (LV) remodeling. "
3.	Rheumatoid Arthritis 10/01/2014 - "In vitro evaluation of effects of sustained anti-TNF release from MPEG-PCL-MPEG and PCL microspheres on human rheumatoid arthritis synoviocytes." 10/01/2014 - "In this study, poly(ε-caprolactone) (PCL) and its copolymer with poly(ethylene glycol), methoxypoly(ethylene glycol)-poly(ε-caprolactone)-methoxypoly(ethylene glycol) microspheres (MPEG-PCL-MPEG) were compared for their prospective success in rheumatoid arthritis treatment. "
4.	Neoplasms (Cancer) 10/15/2012 - "We nasally administered the anti-tumor drug camptothecin (CPT) in solution and in methoxy poly(ethylene glycol) (MPEG)/poly(e-caprolactone) (PCL) amphiphilic block copolymers (MPEG-PCL) and cell penetrating peptide, Tat analog-modified MPEG-PCL (MPEG-PCL-Tat) MPEG-PCL-Tat to rats bearing intracranial glioma tumors and quantified the cytotoxicity against glioma cells, and the therapeutic effects. "
5.	Glioma (Gliomas) 10/15/2012 - "We nasally administered the anti-tumor drug camptothecin (CPT) in solution and in methoxy poly(ethylene glycol) (MPEG)/poly(e-caprolactone) (PCL) amphiphilic block copolymers (MPEG-PCL) and cell penetrating peptide, Tat analog-modified MPEG-PCL (MPEG-PCL-Tat) MPEG-PCL-Tat to rats bearing intracranial glioma tumors and quantified the cytotoxicity against glioma cells, and the therapeutic effects. "

Related Drugs and Biologics

1.	Ethylene Glycol (Monoethylene Glycol)
2.	caprolactone
3.	Hydrogels
4.	dodecanedioic acid
5.	alpha-cyclodextrin
6.	polycaprolactone
7.	Cell-Penetrating Peptides
8.	Therapeutic Uses
9.	Solutions
10.	Camptothecin

Related Therapies and Procedures

1.	Transplantation
2.	Therapeutics
3.	Microspheres (Microsphere)
4.	Injections