Abstract |
A photographic tracking study was performed to facilitate a visual evaluation of the effect of treating psoriatic lesions in a clinical setting with tazarotene 0.05% gel, tazarotene 0.1% gel, tazarotene 0.1% gel plus mometasone furoate as needed for irritation, or tazarotene 0.1% gel plus mometasone furoate. Tazarotene was administered once daily in the evening, and mometasone furoate was administered once daily in the morning, for 12 weeks or until clearance if this occurred first. A total of twenty patients were enrolled in this open-label study. Rates of treatment success (50% or greater improvement in psoriasis) were higher with tazarotene 0.1% monotherapy compared with tazarotene 0.05% monotherapy, and were higher still when tazarotene was used in combination with mometasone furoate. Concurrent use of this steroid also enhanced speed of efficacy, patient satisfaction, and tolerability. Furthermore, long periods of remission were achieved in patients treated with combination tazarotene plus corticosteroid therapy. These findings suggest that tazarotene plus a mid-potency topical corticosteroid is a valuable first-line treatment option for stable plaque psoriasis.
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Authors | Y P Poulin |
Journal | Cutis
(Cutis)
Vol. 63
Issue 1
Pg. 41-8
(Jan 1999)
ISSN: 0011-4162 [Print] United States |
PMID | 9951595
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Dermatologic Agents
- Gels
- Glucocorticoids
- Keratolytic Agents
- Nicotinic Acids
- Pregnadienediols
- Retinoids
- Mometasone Furoate
- tazarotene
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Topics |
- Administration, Topical
- Adult
- Aged
- Anti-Inflammatory Agents
(administration & dosage, adverse effects)
- Dermatologic Agents
(administration & dosage, adverse effects)
- Drug Therapy, Combination
- Female
- Gels
(administration & dosage, adverse effects)
- Glucocorticoids
- Humans
- Keratolytic Agents
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Mometasone Furoate
- Nicotinic Acids
(administration & dosage, adverse effects)
- Patient Satisfaction
- Photography
- Pregnadienediols
(administration & dosage, adverse effects)
- Psoriasis
(drug therapy, pathology)
- Remission Induction
- Retinoids
(administration & dosage, adverse effects)
- Time Factors
- Treatment Outcome
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