Longitudinal studies of neutralizing antibody responses to rotavirus in stools and sera of children following severe rotavirus gastroenteritis.

Abstract

Rotavirus-neutralizing antibody responses in sera and stools of children hospitalized with rotavirus gastroenteritis and then monitored longitudinally were optimally detected by using local rotavirus strains. Stool responses were highest on days 5 to 8 after the onset of diarrhea. Longitudinal monitoring suggested that serum neutralizing antibody responses were a more useful measure of severely symptomatic rotavirus infection than stool responses but that stool antibody responses may be a useful measure of rotavirus immunity.

• Authors: B S Coulson
• Journal: Clinical and diagnostic laboratory immunology (Clin Diagn Lab Immunol) Vol. 5 Issue 6 Pg. 897-901 (Nov 1998) ISSN: 1071-412X [Print] United States
• PMID: 9801354 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral

Topics

• Antibodies, Viral (blood)
• Child, Preschool
• Feces (virology)
• Female
• Gastroenteritis (immunology, virology)
• Humans
• Infant
• Longitudinal Studies
• Male
• Neutralization Tests
• Rotavirus (immunology, isolation & purification)
• Rotavirus Infections (immunology, virology)