Abstract | BACKGROUND: AIMS: To compare four eradication regimens using this treatment in patients with non- ulcer dyspepsia. METHODS: RESULTS: Two hundred and fifty-eight patients were included in the intention-to-treat (ITT) analysis. From the least to the most effective regimen, eradication rates were: O20AC1000: 60.0% (95% CI: 47.6-72.4), O20AC500: 64.1% (52.3-75.8), O40AC1000: 64.2% (52.7-75.7), O40AC500: 74.6% (64.2-85.0) (N.S.). Overall compliance was good in 92% of patients. The most frequent adverse events were diarrhoea and taste impairment, occurring mainly in the high-dose clarithromycin groups. CONCLUSIONS: Eradication rates obtained in this study were lower than those expected on the basis of previously reported studies. This study supports the use of a double dose of omeprazole, although the difference between groups was non-significant, but provides no argument in favour of a high dose of clarithromycin.
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Authors | M A Bigard, J C Delchier, G Riachi, P Thibault, P Barthelemy |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 12
Issue 4
Pg. 383-8
(Apr 1998)
ISSN: 0269-2813 [Print] England |
PMID | 9690730
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Penicillins
- Amoxicillin
- Clarithromycin
- Omeprazole
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Topics |
- Amoxicillin
(administration & dosage)
- Anti-Bacterial Agents
(administration & dosage)
- Anti-Ulcer Agents
(administration & dosage)
- Clarithromycin
(administration & dosage)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Therapy, Combination
- Dyspepsia
(drug therapy, microbiology)
- Female
- Helicobacter Infections
(drug therapy)
- Helicobacter pylori
(drug effects)
- Humans
- Male
- Middle Aged
- Omeprazole
(administration & dosage)
- Patient Compliance
- Penicillins
(administration & dosage)
- Treatment Outcome
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