Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320.

Abstract

Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecular clone NL4-3; the agent was found to have weak activity against one primary HIV-1 isolate, and the agent was inactive against a second primary isolate.

• Authors: C A Stoddart, L Rabin, M Hincenbergs, M Moreno, V Linquist-Stepps, J M Leeds, L A Truong, J R Wyatt, D J Ecker, J M McCune
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 42 Issue 8 Pg. 2113-5 (Aug 1998) ISSN: 0066-4804 [Print] United States
• PMID: 9687417 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anti-HIV Agents
• Oligodeoxyribonucleotides
• Thionucleotides
• oligonucleotide 5320

Topics

• Acquired Immunodeficiency Syndrome (drug therapy)
• Animals
• Anti-HIV Agents (pharmacology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• HIV-1 (drug effects)
• Humans
• Mice
• Mice, SCID
• Oligodeoxyribonucleotides (pharmacology)
• T-Lymphocytes (transplantation)
• Thionucleotides (pharmacology)
• Virus Replication (drug effects)