Immunohistochemical and molecular studies on malignant transformation in mature cystic teratoma of the ovary.

Abstract

OBJECTIVES:

To determine a useful tumor marker for detecting squamous cell carcinoma arising in a dermoid cyst, and to find the molecular pathogenesis of this condition.

METHODS:

In 4 cases of squamous cell carcinoma arising in a dermoid cyst and 22 cases of dermoid cyst, we studied tissue expressions and serum levels of squamous cell carcinoma antigen (SCC), CA 19-9 and CA 125, and the mutation of the p53 tumor suppressor gene.

RESULTS:

Three of 4 malignant cases had either positive SCC expressions or elevated serum SCC levels. The mean serum SCC level in benign cases was below the cut-off level. CA 19-9 and CA 125 were not detected in squamous cell carcinoma. p53 overexpressions were observed in all malignancies.

CONCLUSION:

These results suggested that the serum SCC might be a useful marker for detecting squamous cell carcinoma arising in a dermoid cyst, and that the mutation of p53 might be one of the genetic events in the malignant transformation of a dermoid cyst.

• Authors: T Yoshioka, T Tanaka
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 24 Issue 2 Pg. 83-90 (Apr 1998) ISSN: 1341-8076 [Print] Australia
• PMID: 9631595 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• CA-125 Antigen
• CA-19-9 Antigen
• DNA, Neoplasm
• Serpins
• squamous cell carcinoma-related antigen

Topics

• Adult
• Aged
• Animals
• Antigens, Neoplasm (analysis)
• Biomarkers, Tumor (analysis, genetics, immunology)
• CA-125 Antigen (analysis)
• CA-19-9 Antigen (analysis)
• Carcinoma, Squamous Cell (diagnosis, genetics, pathology)
• Cell Transformation, Neoplastic (genetics, pathology)
• DNA, Neoplasm (analysis, genetics)
• Dermoid Cyst (genetics, pathology)
• Female
• Gene Expression Regulation, Neoplastic
• Genes, p53 (genetics)
• Humans
• Immunoenzyme Techniques
• Immunohistochemistry
• Mice
• Middle Aged
• Ovarian Neoplasms (diagnosis, genetics, pathology)
• Point Mutation
• Polymerase Chain Reaction
• Polymorphism, Single-Stranded Conformational
• Radioimmunoassay
• Sequence Analysis, DNA
• Serpins
• Teratoma (genetics, pathology)