Abstract | BACKGROUND: In subjects undergoing long-term therapy with carbamazepine and/or phenytoin, reduced plasma concentrations of biotin have been reported. However, the diagnostic value of plasma biotin is unclear, in part because of the presence of significant plasma concentrations of biotin metabolites. Pathologic organic aciduria has also been reported with long-term anticonvulsant therapy, suggesting biotin deficiency, but no mechanism leading to deficiency has yet been determined. METHODS: RESULTS: CONCLUSION: These data provide evidence that long-term administration of some anticonvulsants can accelerate biotin catabolism, but the indicators of biotin status conflict.
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Authors | D M Mock, N I Mock, R P Nelson, K A Lombard |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 26
Issue 3
Pg. 245-50
(Mar 1998)
ISSN: 0277-2116 [Print] United States |
PMID | 9523856
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anticonvulsants
- Valerates
- bisnorbiotin
- Carbamazepine
- beta-hydroxyisovaleric acid
- Phenytoin
- Biotin
- D-biotin-d-sulfoxide
- Phenobarbital
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Topics |
- Anticonvulsants
(adverse effects)
- Biotin
(analogs & derivatives, deficiency, metabolism, urine)
- Carbamazepine
(adverse effects)
- Child
- Female
- Humans
- Male
- Phenobarbital
(adverse effects)
- Phenytoin
(adverse effects)
- Valerates
(urine)
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