Protective effects of 3-hydroxy-3-methylglutaric acid in alcohol-induced lipemia.

Abstract

Oral administration of l g of 3-hydroxy-3-methylglutaric acid (HMG) before the ingestion of whiskey and a fatty meal markedly reduced the elevation of serum triglycerides, beta-lipoproteins, phospholipids, and cholesterol in man. In rats receiving an ethanol and corn oil mixture, HMG also inhibited the increase in postprandial serum and liver lipids. A comparative study of HMG and nicotinic acid in rats showed that, therapeutically, 50 mg MHG/kg body weitht is equivalent to 200 mg nicotinic acid/kg body weight in offering almost total protection against lipemic effects of ethanol.

• Authors: S Y Yousufzai, M Siddiqi, A K Abdullah
• Journal: Lipids (Lipids) Vol. 11 Issue 7 Pg. 526-9 (Jul 1976) ISSN: 0024-4201 [Print] United States
• PMID: 948247 (Publication Type: Journal Article)

Chemical References

• Glutarates
• Hydroxy Acids
• Phospholipids
• Triglycerides
• Ethanol
• Cholesterol

Topics

• Adult
• Alcoholic Beverages
• Animals
• Cholesterol (blood, metabolism)
• Ethanol
• Glutarates (pharmacology)
• Humans
• Hydroxy Acids (pharmacology)
• Hyperlipidemias (chemically induced, metabolism)
• Lipid Metabolism
• Liver (drug effects, metabolism)
• Male
• Middle Aged
• Phospholipids (blood, metabolism)
• Rats
• Triglycerides (blood, metabolism)