Meglutol

An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.

Also Known As:

3-Hydroxy-3-methylpentanedioic Acid; beta-Hydroxy-beta-Methylglutarate; 3 Hydroxy 3 methylglutaric Acid; 3 Hydroxy 3 methylpentanedioic Acid; Acid, 3-Hydroxy-3-methylglutaric; Acid, 3-Hydroxy-3-methylpentanedioic; beta Hydroxy beta Methylglutarate; 3-Hydroxy-3-methylglutaric Acid; Pentanedioic acid, 3-hydroxy-3-methyl-

Networked: 11 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Glutarates: 35
        Meglutol: 11
        3-methylglutaric acid: 17
        3-hydroxy-3-ethylglutaric acid: 1
        3-hydroxy-3-methylglutaric anhydride
        gymnopilin 1
        gymnopilin 2
        gymnopilin 3

Related Diseases

1.	Hyperlipidemias (Hyperlipidemia) 07/01/1976 - "Protective effects of 3-hydroxy-3-methylglutaric acid in alcohol-induced lipemia." 09/15/1976 - "3-Hydroxy-3-methylglutaric acid and triton-induced hyperlipidemia in rats."
2.	Atherosclerosis 08/15/1976 - "3-hydroxy-3-methylglutaric acid and experimental atherosclerosis in rats." 11/01/1973 - "3-Hydroxy-3-methylglutaric acid: protective action in experimental atherosclerosis in rabbits."
3.	Gallstones (Gallstone) 10/15/1978 - "Addition of 0.05--0.20% of 3-hydroxy-3-methylglutaric acid to a lithogenic hamster diet resulted in a marked reduction in the incidence of gallstones in hamsters." 10/15/1978 - "Dissolution of gallstones in hamsters by 3-hydroxy-3-methylglutaric acid."
4.	Hyperammonemia 07/02/1979 - "The urine of a child who presented with hyperammonemia was found to contain elevated levels of 3-hydroxy-3-methylglutaric acid, 3-methylglutaconic acid and 3-methylglutaric acid. "
5.	Prostatitis 01/01/2022 - "Six diagnostic models distinguished BPH from prostatitis: citric acid (AUC=0.926), pyroglutamic acid (AUC=0.864), phenyllactic acid (AUC=0.850), ethylmalonic acid (AUC=0.843), 3-hydroxy-3-methylglutaric acid (AUC=0.817), and hippuric acid (AUC=0.791). "

Related Drugs and Biologics

1.	3-methylglutaconic acid
2.	Citric Acid (Citrate)
3.	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)
4.	Orotic Acid
5.	LDL Cholesterol
6.	Acids
7.	Beta ketothiolase deficiency
8.	methylcyanocarbamate dimer
9.	ethylmalonic acid (ethylmalonate)
10.	3-methylglutaric acid