Alterations of male Wistar rat jejunum induced by Dodine (n-dodecylguanidine acetate).

Abstract

The effect of Dodine on the intestine was studied after a single administration of 1000 mg/kg, which corresponds to the LD50 in male Wistar rats. At this dose, a significant decrease in body weight was observed, accompanied by diarrhea, which may be associated with intestinal alterations. The chemical induced a significant reduction of the protein content and in sucrase activity in the jejunum. Morphological alterations included a significant decrease in crypt height and in villus length and depth. The intestinal modifications observed in animals after Dodine administration may explain the observed loss in body weight and diarrhea.

• Authors: M Mitjans, M P Vinardell
• Journal: Journal of toxicology and environmental health (J Toxicol Environ Health) Vol. 52 Issue 6 Pg. 545-56 (Dec 26 1997) ISSN: 0098-4108 [Print] United States
• PMID: 9397185 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fungicides, Industrial
• Guanidines
• Proteins
• dodine
• Sucrase

Topics

• Animals
• Body Weight (drug effects)
• Fungicides, Industrial (toxicity)
• Guanidines (toxicity)
• Intestinal Mucosa (cytology, drug effects)
• Jejunum (cytology, drug effects, metabolism)
• Male
• Microvilli (enzymology)
• Proteins (metabolism)
• Rats
• Rats, Wistar
• Sucrase (drug effects, metabolism)