Aspirin treatment of the low-dose-endotoxin-treated pregnant rat: pathophysiologic and immunohistologic aspects.

Abstract	In the present study, we evaluated the effect of low-dose aspirin (acetylsalicylic acid (ASA); 1.0 mg/kg daily) on blood pressure, albumin excretion, glomerular fibrinogen deposits, and glomerular (basement) membrane-bound adenosine diphosphatase (ecto-ADPase) activity, as well as on glomerular inflammation in pregnant rats infused with low-dose endotoxin (1.0 mg/kg). Rats (day 14 of pregnancy) were infused with endotoxin (ET rats) or saline (control rats) and received ASA in their drinking water. These rats were compared with non-ASA-treated rats. Blood pressure and albumin excretion were measured from day 15 to day 21, and glomerular fibrinogen and ecto-ADPase activity were measured at day 21. Glomerular inflammation was evaluated at various times after the start of the infusion. The results show that treatment with ASA had a significant beneficial effect on hypertension and inflammation induced by endotoxin in pregnant rats, whereas it reduced albumin excretion and glomerular fibrinogen deposits in some of the rats.
Authors	M M Faas, G A Schuiling, J F Baller, N Valkhof, W W Bakker
Journal	The Journal of laboratory and clinical medicine (J Lab Clin Med) Vol. 130 Issue 5 Pg. 496-508 (Nov 1997) ISSN: 0022-2143 [Print] United States
PMID	9390637 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Cell Adhesion Molecules Endotoxins Serum Albumin endotoxin, Escherichia coli Apyrase Aspirin
Topics	Albuminuria Animals Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use) Apyrase (metabolism) Aspirin (administration & dosage, therapeutic use) Blood Pressure (drug effects) Cell Adhesion Molecules (analysis) Endotoxins (toxicity) Female Glomerular Filtration Rate (drug effects) Glomerulonephritis (drug therapy, etiology) Hypertension (drug therapy, etiology) Kidney Glomerulus (drug effects, metabolism, pathology) Leukocyte Count Neutrophils Pregnancy Pregnancy Complications (drug therapy) Proteinuria (drug therapy) Rats Rats, Wistar Serum Albumin (analysis)

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