[The effect of the glycoside strophanthin K on the ultrastructure of the cardiomyocytes in the pro-oxidant zone of the myocardium in rats with experimental heart failure].

Abstract

The effect of the cardiotonic strophanthin K on the ultrastructure of cardiomyocytes in the "pro-oxidant zone" in hypercatecholemia was studied in Wistar rats with experimental cardiac insufficiency (ECI). In ECI two differently directed processes, compensatory and degenerative, develop in the "pro-oxidant zone". After administration of strophanthin K the degenerative processes in the "pro-oxidant zone" increased: the number of degenerated cardiomyocytes was 41.9 +/- 1.4% in ECI and 85.35 +/- 3.4% after strophanthin administration (p > 0.99).

• Authors: I N Chernysh, V B Sadovnikov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1997 Jul-Aug Vol. 60 Issue 4 Pg. 29-31 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie glikozida strofantina K na ul'trastrukturu kardiomiotsitov prooksidantnoĭ zony miokarda u krys s éksperimental'noĭ serdechnoĭ nedostatochnost'iu.
• PMID: 9376752 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cardiotonic Agents
• Strophanthins
• strophanthin K

Topics

• Animals
• Cardiotonic Agents (pharmacology, therapeutic use)
• Disease Models, Animal
• Female
• Heart (drug effects)
• Heart Failure (chemically induced, drug therapy, metabolism, pathology)
• Male
• Microscopy, Electron
• Myocardium (metabolism, ultrastructure)
• Necrosis
• Rats
• Rats, Wistar
• Strophanthins (pharmacology, therapeutic use)