Abstract |
Effect of TYB-2285 and its metabolites on immune responses by peripheral blood mononuclear cells (PBMC) from children with bronchial asthma was investigated. TYB-2285 and its metabolites have immunosuppressive activity for the proliferation by Df-stimulated patients' lymphocytes. Concanavalin A (Con A)-activated peripheral blood mononuclear cells (PBMC) from the patients were not affected by the same treatment. The results indicate that TYB-2285 and its metabolites are capable of suppressing antigen-induced 3H-thymidine (3H-TdR) uptake but not the response induced by Con A. Interferon-gamma (IFN-gamma) production by Df-stimulated PBMC from patients with active asthma, which was lower than that of normal lymphocytes, were reversed beyond the levels of that in normal subjects. Thus reduced production of IFN-gamma by Df-stimulated patients' lymphocytes was increased by TYB-2285 and its metabolites in a dose-dependent manner. This phenomenon was not observed in lymphocytes from normal subjects. Furthermore, TYB-2285 inhibited IL-4 production induced by Df antigen in asthmatic patients' lymphocytes. Taken, together, TYB-2285 could work as a weak immunosuppressant to modify lymphocytes' responses to allergen in patients with bronchial asthma. These data underscore the potential benefit for the patients with bronchial asthma.
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Authors | K Kou, M Hayashi, T Nakajima, I Yoshizawa, Y Kawano, Y Shikishima, T Noma |
Journal | Arerugi = [Allergy]
(Arerugi)
Vol. 46
Issue 6
Pg. 502-10
(Jun 1997)
ISSN: 0021-4884 [Print] Japan |
PMID | 9277001
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Allergic Agents
- Nitriles
- 3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile
- Interleukin-4
- Interferon-gamma
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Topics |
- Adolescent
- Animals
- Anti-Allergic Agents
(pharmacology)
- Asthma
(immunology)
- Cells, Cultured
- Child
- Child, Preschool
- Humans
- Interferon-gamma
(biosynthesis)
- Interleukin-4
(biosynthesis)
- Lymphocyte Activation
(drug effects)
- Lymphocytes
(immunology, metabolism)
- Mites
(immunology)
- Nitriles
(pharmacology)
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