Sphenoid sinus localization of multiple myeloma revealing evolution from benign gammopathy.

Abstract

BACKGROUND:

Plasma-cell neoplasms of the head and neck include extramedullary plasmacytoma and solitary plasmocytoma of bone or may represent a local manifestation of multiple myeloma. Involvement of sphenoid sinus has been rarely reported in multiple myeloma.

METHODS:

We present the case of a 77-year-old man with a 3-year-history of benign monoclonal IgG-lambda gammopathy who developed left sixth-nerve palsy and malaise.

RESULTS:

Computed tomography scan and magnetic resonance imaging scan disclosed a large soft-tissue mass of the sphenoid sinus with bone destruction. Sphenoid sinus biopsy revealed an IgG monoclonal plasma cell neoplasm. Diagnosis of multiple myeloma stage IA was then established.

CONCLUSIONS:

Diagnosis of plasma-cell neoplasm should be considered in sphenoid sinus tumors and depends upon histologic examination. This case enlightens the relationships between monoclonal benign gammopathy and plasma-cell neoplasms of the head and neck which constitute a continuum of B-cell lymphoproliferative disorders.

• Authors: C Bachmeyer, V Levy, M Carteret, O Laccourreye, C Danel, A Le Tourneau, R Zittoun, G Grateau
• Journal: Head & neck (Head Neck) Vol. 19 Issue 4 Pg. 347-50 (Jul 1997) ISSN: 1043-3074 [Print] United States
• PMID: 9213114 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin lambda-Chains

Topics

• Aged
• Humans
• Immunoglobulin lambda-Chains (blood)
• Magnetic Resonance Imaging
• Male
• Monoclonal Gammopathy of Undetermined Significance (blood, pathology)
• Multiple Myeloma (blood, diagnosis, diagnostic imaging)
• Paranasal Sinus Neoplasms (blood, diagnostic imaging, pathology)
• Sphenoid Sinus (diagnostic imaging, pathology)
• Tomography, X-Ray Computed