[Measurement of antibody titers to chlamydial infection and effects of levofloxacin in cystic cervicitis and chlamydial infection].

Abstract

Generally, clinical symptoms such as abnormal leukorrhea are caused by C. trachomatis, an ordinary bacteria in cervical infection. The effects of levofloxacin administration at a dose of 300 mg/day for 5-14 days were investigated in the subjects (n = 66) after the discussion of cystic cervicitis. The treatment was made in combination with chloramphenicol-solcoseryl tablet for vaginal use. And it was demonstrated that treatment was effective in all subjects. Then, Sero IPALISA, an examination of IgA/IgG antibody was conducted for the screening of Chlamydia infection (n = 258). The rate of antibody-positive case was 48/160 (30.0%) for the non-pregnant women and 26/98 (26.5%) for the pregnant. The occurrence rates for the women singing in 15-24 and 35-39 years of age were 50 and 41%, respectively. The results from the measurement of the antibody titer were as follows: the rate of IgA/IgG positive care was 61/87 for IgA and 56/87 for IgG when the cut-off index was 1.11 or more. The rates for both antibody were 11/87 (12.6%) and 24/87 (27.6%) for the indexes of 1.11-3.00 and 3.01 or more, respectively. Next, one to three courses levofloxacin at 300 mg/day for 14 days were given to 48 non-pregnant subjects infected with Chlamydia and one to two courses of clarithromycin at 400 mg/day for 14 days were given to 26 pregnant subjects. Side effects have not been noted in any care and there was no changes in the IgA/IgG antibody titer depending on these treatments.

• Authors: T Chimura
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 50 Issue 5 Pg. 479-84 (May 1997) ISSN: 0368-2781 [Print] Japan
• PMID: 9212369 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Antibodies, Bacterial
• Immunoglobulin A
• Immunoglobulin G
• Actihaemyl
• Chloramphenicol
• Levofloxacin
• Ofloxacin
• Clarithromycin

Topics

• Actihaemyl (administration & dosage)
• Administration, Oral
• Adolescent
• Aged
• Anti-Bacterial Agents (administration & dosage)
• Anti-Infective Agents (administration & dosage)
• Antibodies, Bacterial (analysis)
• Chlamydia Infections
• Chlamydia trachomatis (immunology)
• Chloramphenicol (administration & dosage)
• Clarithromycin (administration & dosage)
• Drug Therapy, Combination (administration & dosage)
• Female
• Humans
• Immunoglobulin A (analysis)
• Immunoglobulin G (analysis)
• Levofloxacin
• Middle Aged
• Ofloxacin (administration & dosage)
• Pessaries
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy, microbiology)
• Uterine Cervicitis (drug therapy, microbiology)