Increases in the effects of albendazole on Echinococcus multilocularis metacestodes by the dipeptide methyl ester (Phe-Phe-OMe).

Abstract

Three months after infection with Echinococcus multilocularis, Mongolian gerbils were given either the dipeptide methyl ester (Phe-Phe-OMe) or a combination of Phe-Phe-OMe plus albendazole to treat alveolar echinococcosis. Each drug was given orally at the daily dose of 50 mg/kg of body weight following various administration regimens. Histologic and ultrastructural studies of parasites recovered from infected gerbil tissues showed that the dipeptide methyl ester increases the effect of albendazole.

• Authors: M E Sarciron, N Walchshofer, S Walbaum, C Arsac, J Descotes, A F Petavy, J Paris
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 56 Issue 2 Pg. 226-30 (Feb 1997) ISSN: 0002-9637 [Print] United States
• PMID: 9080884 (Publication Type: Journal Article)

Chemical References

• Anthelmintics
• Dipeptides
• Drug Combinations
• Serine Proteinase Inhibitors
• phenylalanylphenylalanine methyl ester
• Albendazole

Topics

• Albendazole (pharmacology, therapeutic use, toxicity)
• Animals
• Anthelmintics (pharmacology, therapeutic use, toxicity)
• Dipeptides (pharmacology, therapeutic use, toxicity)
• Drug Combinations
• Echinococcosis, Hepatic (drug therapy)
• Echinococcus (drug effects, ultrastructure)
• Female
• Gerbillinae
• Male
• Mice
• Microscopy, Electron
• Serine Proteinase Inhibitors (pharmacology, therapeutic use, toxicity)