[The effect of adenosine receptor agonists on the normal cerebral blood flow and in subsequent ischemia].

Abstract

Nonconformity of arterial pressure (AP) and cerebral blood flow (CBF) to the normal distribution necessitates the use of nonparametric criteria. Cerebroprotective doses of adenosine and cyclohexyladenosine significantly decrease AP and reduce (or virtually do not change) CBF. In conditions of following occlusion of carotid arteries AP is lower and CBF is somewhat better or the same as in the control (ischemia). Changes in CBF can be only an additional contribution to the high cerebroprotective effect of the A-receptor agonists.

• Authors: V I Kulinskiĭ, G Z Sufianova, L A Usov, E N Ekimov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1996 May-Jun Vol. 59 Issue 3 Pg. 37-9 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie agonistov adenozinovykh retseptorov na mozgovoĭ krovotok v norme i pri posleduiushcheĭ ishemii.
• PMID: 8974582 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Purinergic P1 Receptor Agonists
• Vasodilator Agents
• N(6)-cyclohexyladenosine
• Adenosine

Topics

• Adenosine (analogs & derivatives, pharmacology, therapeutic use)
• Animals
• Blood Pressure (drug effects)
• Brain Ischemia (drug therapy, etiology, physiopathology)
• Cerebrovascular Circulation (drug effects)
• Drug Evaluation, Preclinical
• Female
• Male
• Purinergic P1 Receptor Agonists
• Rats
• Statistics, Nonparametric
• Vasodilator Agents (pharmacology, therapeutic use)