Sea-blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat-emulsion sources: a clinicopathologic study of seven cases.

Abstract

Bone marrow examination revealed a lipid-laden histiocytosis in seven patients undergoing long-term total parenteral nutrition necessitated by extensive short-bowel surgical resection. Clinical abnormalities occurred during this treatment which required bone marrow examination. These included hepatosplenomegaly and peripheral blood cytopenia; the median time to the detection of these abnormalities was 64 months. The most striking change within the bone marrow was the presence of many pigment-laden histiocytes which had the typical morphology of sea-blue histiocytes seen in the so-called idiopathic sea-blue histiocyte syndrome. The occurrence of sea-blue histiocytosis in the bone marrow in association with long-term parenteral nutrition for short-bowel syndrome has not, to our knowledge, been reported previously and should now be considered in the differential diagnosis of bone marrow sea-blue histiocytosis.

• Authors: C Bigorgne, A Le Tourneau, B Messing, B Rio, V Giraud, T Molina, J Audouin, J Diebold
• Journal: British journal of haematology (Br J Haematol) Vol. 95 Issue 2 Pg. 258-62 (Nov 1996) ISSN: 0007-1048 [Print] England
• PMID: 8904878 (Publication Type: Journal Article)

Chemical References

• Fat Emulsions, Intravenous

Topics

• Adult
• Aged
• Bone Marrow (pathology)
• Fat Emulsions, Intravenous (adverse effects)
• Humans
• Macrophages (pathology)
• Middle Aged
• Parenteral Nutrition (adverse effects)
• Sea-Blue Histiocyte Syndrome (etiology, pathology)