Histiocytosis

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228 relevant articles (6 outcomes, 13 trials/studies) found for this Disease

Description: General term for the abnormal appearance of histiocytes in the blood. Based on the pathological features of the cells involved rather than on clinical findings, the histiocytic diseases are subdivided into three groups: HISTIOCYTOSIS, LANGERHANS CELL; HISTIOCYTOSIS, NON-LANGERHANS CELL; and HISTIOCYTIC DISORDERS, MALIGNANT.

Also Known As:

Histiocytoses

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases

Lymphatic Diseases: 1961

Histiocytosis: 228

Langerhans-Cell Histiocytosis: 659

Non-Langerhans-Cell Histiocytosis: 20

Malignant Histiocytic Disorders

Related Diseases

1.	Neoplasms (Cancer)
2.	Lymphoma (Lymphomas)
3.	Heart Failure
4.	Syndrome
5.	Sarcoidosis (Schaumann Disease)

Experts

1.	Wechsler, Bertrand: 1 article (06/2008)
2.	Brousse, Nicole: 1 article (06/2008)
3.	Haroche, Julien: 1 article (06/2008)
4.	Piette, Jean-Charles: 1 article (06/2008)
5.	Amoura, Zahir: 1 article (06/2008)
6.	Salvatierra, Juan: 1 article (06/2008)
7.	Charlotte, Frédéric: 1 article (06/2008)
8.	Graux, Carlos: 1 article (06/2008)
9.	Ishiko, A: 1 article (05/2008)
10.	Ouchi, T: 1 article (05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Histiocytosis:

1.	Etoposide (VP 16)FDA LinkGeneric 06/01/1990 - "Additionally, VP-16 is considered to be effective for the treatment of histiocytosis." 05/01/1994 - "VP-16 and the treatment of histiocytosis." 01/01/1994 - "Data on the risk of etoposide-associated (therapy-induced) malignancy, in the setting of histiocytosis, are reviewed. " 06/01/1990 - "The efficacy rate for VP-16 alone was 87.5% for primary cases of ANLL and 100% for primary cases of histiocytosis. " 09/01/1991 - "The results suggested that the treatment with etoposide might be effective for reactive histiocytosis and the related refractory state to platelet transfusion during therapy for leukemia." Order ALL the reference details at left...
2.	Vinblastine (Vinblastine Sulfate)FDA Link 11/01/1982 - "Response of nodular non-X histiocytosis to vinblastine." 03/01/2004 - "[Vinblastine treatment for extensive non-X histiocytosis (xanthoma disseminatum)]" 03/01/1970 - "[Remission of acute histiocytosis with lung involvement after treatment with vinblastine and prednisone]" Order ALL the reference details at left...
3.	Cladribine FDA LinkGeneric 01/01/1997 - "Indeterminate cell histiocytosis treated successfully with 2-chlorodeoxyadenosine." 09/01/2008 - "Aggressive intermediate cell histiocytosis successfully treated by 2-chlorodeoxyadenosine." Order ALL the reference details at left...
4.	Prednisone (Sone)FDA LinkGeneric 03/01/1970 - "[Remission of acute histiocytosis with lung involvement after treatment with vinblastine and prednisone]" 06/01/1977 - "A patient with systemic histiocytosis was treated with hemibody irradiation, vincristine, and prednisone. " Order ALL the reference details at left...
5.	FuraginIBA 01/01/1999 - "Further 19 positive results were found in a group of 251 patients with other diseases: 1 of 4 pts with Churg-Strauss syndrome, 1 of 2 with pulmonary renal syndrome, 5 of 28 with connective tissue diseases, 1 of 21 with tuberculosis, 1 of 23 with sarcoidosis, 1 of 6 with histiocytosis, 3 of 11 with hypersensitivity pneumonitis, 1 (lymphoma) of 34 with neoplasms, 1 of 20 with pulmonary fibrosis, 1 of 8 with cardiac failure, 1 of 5 with pleural fluid, 1 of 10 pneumoconiosis and toxic reactions (after furagin), 1 of 6 with BOOP. " Order ALL the reference details at left...
6.	S100 Proteins (S 100 Protein)IBA 07/01/1996 - "Negative S-100 protein in the immunohistochemical study and the absence of Birbeck granules on an electromicroscopic study excluded the possibility of Langerhan's histiocytosis. " 09/01/2006 - "Like other histiocytoses, such as Langerhans cell histiocytosis, immunohistochemical techniques reveal lipid-laden histiocytes; however, unlike the other types, Erdheim-Chester histiocytes stain negatively for S 100 protein and do not contain Birbeck granules." 03/01/1998 - "A positive reaction for S-100 protein is conventionally accepted as a useful differentiating feature between histiocytosis X and non-X histiocytosis such as JXG and RH. " 01/01/1988 - "The results show that antibodies to S-100 protein are useful in distinguishing the "X" (Langerhans' cell) from the "non-X"types of histiocytosis, and cast some shadow on the usefulness of the lectin PNA as a histiocytic marker. " 10/01/1992 - "Antibodies to XIIIa, CD34, S-100 protein, and macrophage antigen (MAC 387) were tested on formalin-fixed, paraffin-embedded tissue sections from normal mucosa, peripheral fibroma (PF), peripheral ossifying fibroma (POF), peripheral giant cell granuloma (PGCG), pyogenic granuloma (PG), lymphangioma (La), benign fibrous histiocytoma (BFH), idiopathic histiocytosis (IH), angiofibroma (Af) using an ABC immunoperoxidase technique. " Order ALL the reference details at left...
7.	Immunoglobulins (Immunoglobulin)IBA 09/01/2008 - "A very rare form is the deposition of monoclonal immunoglobulin in the form of amorphous matter (light-chain deposition disease) or in the form of crystals within tissue histiocytes (crystal storing histiocytosis). " 12/01/2006 - "CONCLUSIONS: Phagocytosis of crystals of immunoglobulins by histiocytes (crystals storing histiocytosis) is a rare symptom associated most often with lymphoproliferative disease. " 02/01/2006 - "Crystal storing histiocytosis is a rare phenomenon in which macrophages accumulate light chain or immunoglobulin crystalline inclusions. " 07/01/2004 - "Crystal-storing histiocytosis (CSH) with massive accumulation of particulate immunoglobulins is a rare phenomenon accompanying B-cell dyscrasias. " 01/01/2002 - "In all cases, crystal formation is associated with accumulation of histiocytes containing light chain or immunoglobulin inclusions, and the disorder has been termed crystal-storing histiocytosis. " Order ALL the reference details at left...
8.	AntigensIBA 04/01/2003 - "Definitive diagnosis of histiocytosis is made by histopathology including immunohistochemical detection of S-100 and CD1a antigens. " 04/01/1994 - "The two girls with germ cell tumor shared an identical human leukocyte antigen, whereas the sister with histiocytosis shared one identical haplotype with them. " 12/01/1990 - "Because regressing atypical histiocytosis may demonstrate aberrant thymic differentiation antigen expression and T-cell receptor gene rearrangements, initial lymph node involvement, and eventuation in conventional lymphoma in some cases, the alternative term regressing-phase anaplastic lymphoma is proposed as a more accurate designation for this entity." 02/01/1995 - "Nevertheless, these xanthomas showed an antigen expression pattern similar to that found in noninfectious granulomas (CD1a-, MS-1-, CD11c+, MRP-8/-14+, 25F9+, RM 3/1+/-, CD36(+), indicating that normolipemic papular xanthomatosis may be reactive process and should not be included among the true cutaneous non-Langerhans cell histiocytoses." 12/01/1994 - "RM 3/1 antigen shows a similar, but broader expression pattern including non-Langerhans cell histiocytoses, xanthelasmata palpebrarum, foreign body granulomas, granuloma annulare, and cellular type dermatofibroma. " Order ALL the reference details at left...
9.	ParaffinIBA 03/01/1995 - "[Possibilities and limits of paraffin-embedded cell markers in diagnosis of primary cutaneous histiocytosis]" 04/01/1994 - "Paraffin blocks from 38 cases with superficial lymph nodes exhibiting reactive histiocytosis with debris-like necrosis and neutrophil infiltration were studied by means of polymerase chain reaction for amplifying the repetitive DNA sequence (123pb fragment) specific for mycobacterium tuberculosis (M.TB-PCR), BCG immunohistochemistry (BCG-IHC) as well as acid fast stain (AF) for M.TB/MOTT (mycobacterium other than tuberculosis). " 10/01/1989 - "The diagnostic value of the Ber-H2 MoAb was most significant for a group of anaplastic large-cell (ALC) lymphomas (formerly frequently referred to as malignant histiocytosis or regressive atypical histiocytosis), of which more than 50 cases could be investigated, owing to applicability in paraffin sections. " 02/01/1996 - "Histopathologic effects seen in F-344 rats include mesenteric lymph node histiocytosis, liver granulomas, and inflammation of the mitral valve (only seen with paraffin waxes). " 10/01/1992 - "Antibodies to XIIIa, CD34, S-100 protein, and macrophage antigen (MAC 387) were tested on formalin-fixed, paraffin-embedded tissue sections from normal mucosa, peripheral fibroma (PF), peripheral ossifying fibroma (POF), peripheral giant cell granuloma (PGCG), pyogenic granuloma (PG), lymphangioma (La), benign fibrous histiocytoma (BFH), idiopathic histiocytosis (IH), angiofibroma (Af) using an ABC immunoperoxidase technique. " Order ALL the reference details at left...
10.	Growth Hormone (Somatotropin)IBA 05/01/1998 - "STUDY DESIGN: Retrospective analysis of data from the Kabi (Pharmacia & Upjohn) international growth database (KIGS) for 82 children with Langerhan's cell histiocytosis treated with recombinant growth hormone. " 05/01/1998 - "CONCLUSIONS: Growth hormone replacement treatment for patients with Langerhan's cell histiocytosis with growth hormone deficiency is beneficial and safe." 05/01/1998 - "OBJECTIVES: To assess the impact of growth hormone on growth and the underlying disease in children with growth hormone deficiency as a result of Langerhan's cell histiocytosis. " 05/01/1998 - "Growth hormone replacement in patients with Langerhan's cell histiocytosis." 12/01/1979 - "[Growth hormone deficiency during the course of histiocytoses. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1976 - "The prognosis for children with disseminated histiocytosis, previously considered poor, has improved dramatically with the application of modern principles of chemotherapy. " 05/01/2007 - "He received chemotherapy for histiocytosis that was diagnosed when he was 3 years, 6 months years old. " 11/01/2006 - "He received chemotherapy for histiocytosis and was diagnosed at 3.5 years. " 02/01/2004 - "We suggest that chemotherapy should be considered at an early stage in the more aggressive subtypes of non-Langerhans cell histiocytoses." 12/01/1992 - "Thus, reactive histiocytosis is one of the severe complications in patients with AML undergoing chemotherapy." Order ALL the reference details at left...
2.	Aftercare (After-Treatment) 01/01/1977 - "On the occasion of a second lung biopsy in one case could be seen that after treatment no more histiocytosis-specific substrate was existing. " 03/01/1998 - "[Langerhans histiocytosis in adults: cutaneous and mucous lesion regression after treatment with thalidomide]" 03/01/1970 - "[Remission of acute histiocytosis with lung involvement after treatment with vinblastine and prednisone]" Order ALL the reference details at left...
3.	Platelet Transfusion (Blood Platelet Transfusions) 09/01/1991 - "The results suggested that the treatment with etoposide might be effective for reactive histiocytosis and the related refractory state to platelet transfusion during therapy for leukemia." 09/01/1991 - "[Effectiveness of etoposide on reactive histiocytosis and refractory state to platelet transfusion during therapy of leukemia: case report]" Order ALL the reference details at left...
4.	Transplants (Transplant) 12/15/2005 - "A 12-month-old boy underwent unrelated donor umbilical cord blood transplant (UCBT) for refractory Langerhan's cell histiocytosis. " 04/01/2004 - "The patient with erythrophagocytic histiocytosis underwent a cord-blood stem cell transplant. " 12/01/1994 - "Bone marrow histiocytosis and autologous graft failure: possible implications." 01/01/2008 - "Two transplant patients, one with a medical history of histiocytosis and the other with a history of osteomyelitis of the maxilla without a recipient socket, were also excluded from this study. " Order ALL the reference details at left...
5.	Combination Drug Therapy (Combination Chemotherapy) 08/01/1977 - "This is the second study of combination chemotherapy with individually effective agents that has failed to improve the response rates in histiocytosis patients with poor prognostic indicators." Order ALL the reference details at left...

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