[A case of Borrmann type 4 gastric cancer successfully treated with MTX and 5-FU therapy through the hepatic artery].

Abstract

A 73-year-old male was diagnosed as having a Borrmann type 4 gastric cancer with multiple liver metastases. Total gastrectomy (D2) with hepatic arterial cannulation was performed. Hepatic arterial infusion therapy of MTX (50 mg or 100 mg/body) and 5-FU (500 mg or 750 mg/body) was started postoperatively. A total dose of 1,150 mg of MTX and 6,250 mg of 5-FU caused a marked decrease in the volume of liver metastases and the effect remained for 8 months (partial response). Regarding drug concentrations, serum MTX levels rapidly decreased after bolus injection through hepatic artery and corresponded to those of intravenous injection as reported elsewhere. Serum 5-FU levels were maintained as low as 1.2 micrograms/ml during 2-hr continuous infusion and rapidly decreased after the end of the infusion. These results indicate that hepatic arterial infusion therapy of MTX and 5-FU may be safe and feasible for multiple liver metastases of Borrmann type 4 gastric cancer.

• Authors: T Gonda, H Ishida, I Hojo, M Ando, H Fukunari
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 23 Issue 11 Pg. 1561-3 (Sep 1996) ISSN: 0385-0684 [Print] Japan
• PMID: 8854805 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Fluorouracil
• Methotrexate

Topics

• Adenocarcinoma (drug therapy, secondary)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Fluorouracil (administration & dosage)
• Gastrectomy
• Hepatic Artery
• Humans
• Infusions, Intra-Arterial
• Liver Neoplasms (drug therapy, secondary)
• Male
• Methotrexate (administration & dosage)
• Stomach Neoplasms (pathology, therapy)