| Abstract | A 73-year-old male was diagnosed as having a Borrmann type 4 gastric cancer with multiple liver metastases. Total gastrectomy (D2) with hepatic arterial cannulation was performed. Hepatic arterial infusion therapy of MTX (50 mg or 100 mg/body) and 5-FU (500 mg or 750 mg/body) was started postoperatively. A total dose of 1,150 mg of MTX and 6,250 mg of 5-FU caused a marked decrease in the volume of liver metastases and the effect remained for 8 months (partial response). Regarding drug concentrations, serum MTX levels rapidly decreased after bolus injection through hepatic artery and corresponded to those of intravenous injection as reported elsewhere. Serum 5-FU levels were maintained as low as 1.2 micrograms/ml during 2-hr continuous infusion and rapidly decreased after the end of the infusion. These results indicate that hepatic arterial infusion therapy of MTX and 5-FU may be safe and feasible for multiple liver metastases of Borrmann type 4 gastric cancer. |
| Authors | T Gonda, H Ishida, I Hojo, M Ando, H Fukunari
(Affiliation: Dept. of Surgery, Niigata Prefectural Tokamachi Hospital.)
|
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 23
Issue 11
Pg. 1561-3
(Sep 1996)
ISSN: 0385-0684 JAPAN |
| PMID | 8854805
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Fluorouracil
- Methotrexate
|
| Topics |
- Adenocarcinoma
(drug therapy, secondary)
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Combined Modality Therapy
- Fluorouracil
(administration & dosage)
- Gastrectomy
- Hepatic Artery
- Humans
- Infusions, Intra-Arterial
- Liver Neoplasms
(drug therapy, secondary)
- Male
- Methotrexate
(administration & dosage)
- Stomach Neoplasms
(pathology, therapy)
|
