HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effect of a hepatoprotective agent, YH-439, on the pharmacokinetics of furosemide and azosemide in rats.

Abstract
The effect of YH-439 pretreatment on the pharmacokinetics of furosemide and azosemide was investigated after intravenous (iv) administration of furosemide, 6 mg per whole body weight, and azosemide, 10 mg per kg body weight, to rats pretreated with 3 consecutive daily oral administration of YH-439, 200 mg per kg body weight. The nonrenal clearance of furosemide (2.20 versus 3.53 ml/min/kg) increased significantly, and the 24 h-urinary excretion of furosemide (both the amount and percentages of iv dose) decreased significantly in the YH-439 treated rats when compared with those in the control rats. The results were unexpected since the metabolism of furosemide increased by pretreatment with phenobarbital (CYP2B inducer) and YH-439 pretreatment failed to affect CYP2B expression. The increased metabolism of furosemide by pretreatment with YH-439 could be due to other enzyme(s) induced by pretreatment with YH-439. Pharmacokinetic parameters of azosemide were not significantly different between the two groups of rats except t(1/2), MRT, and V(ss). The results were unexpected since azosemide metabolism increased with 3-methylchloranthane (3-MC, CYP1A inducer) and YH-439 pretreatment increased CYP1A expression. Above data indicate that the expression of CYP1A by treatment with YH-439 was not considerable when compared with that with 3-MC.
AuthorsS H Kim, K J Park, W H Yoon, J W Lee, N D Kim, M G Lee
JournalResearch communications in molecular pathology and pharmacology (Res Commun Mol Pathol Pharmacol) Vol. 91 Issue 2 Pg. 233-44 (Feb 1996) ISSN: 1078-0297 [Print] UNITED STATES
PMID8832915 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Diuretics
  • Sulfanilamides
  • Thiazoles
  • YH 439
  • Furosemide
  • azosemide
Topics
  • Animals
  • Area Under Curve
  • Diuretics (administration & dosage, pharmacokinetics)
  • Drug Interactions
  • Drug-Induced Liver Injury (prevention & control)
  • Furosemide (administration & dosage, pharmacokinetics)
  • Half-Life
  • Injections, Intravenous
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Sulfanilamides (administration & dosage, pharmacokinetics)
  • Thiazoles (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: