Perfluorodecalin is a
perfluorocarbon liquid used intraoperatively in
retinal detachment repair. It is usually removed at the end of the procedure; however, residual amounts may be retained when poor corneal clarity or intraocular
hemorrhage obscures the view. No clinical reports exist on the consequences of retained
perfluorodecalin in the anterior segment. We report five cases in which
perfluorodecalin was in prolonged contact with the cornea. The period of time for corneal pathology to occur and the role
perfluorodecalin played in the etiology of such changes is discussed. A total of 348 patients with
retinal detachments in one
retinal practice underwent repair using pars plana
vitrectomy combined with intraoperative
perfluorodecalin between January 1992 and May 1994. Postoperatively, residual
perfluorodecalin was observed in the anterior chamber in contact with the corneal endothelium in five patients. The patients were followed clinically for a period of up to 18 months. Four of five patients developed corneal changes from prolonged contact with
perfluorodecalin.
Corneal edema developed in the area
perfluorodecalin-endothelial contact in three of five eyes. The period of
perfluorodecalin-endothelial contact before corneal decompensation occurred ranged from 4 to 13 weeks. Two eyes required
penetrating keratoplasties for progressive
corneal edema.
Corneal edema was reversed in one eye after removal of
perfluorodecalin from the anterior chamber via multiple paracentesis. One of the remaining eyes developed deep corneal vascularization without
edema in the area of
perfluorodecalin contact after 12 months. These observations suggest that corneal toxicity may be induced by intraocular
perfluorodecalin if it is allowed direct contact with the corneal endothelium for periods as short as 1 month. Some of these changes may be reversible if
perfluorodecalin is aspirated from the anterior chamber. Further investigations are required to examine
perfluorodecalin-induced corneal toxicity.