Abstract | BACKGROUND: METHODS: RESULTS: All of the patients with normal renal function, whether they had diabetes mellitus (n=16), rheumatoid arthritis (n=10), systemic lupus erythematosus (n=12) or chronic glomerulonephritis (n=14), had serum pro-gastrin-releasing peptide concentrations less than 46 ng/l, the upper limit in normal subjects. In contrast, 14 or 16 patients (88%) with small-cell lung carcinoma, who had normal renal function, and 25 of 26 (96%) patients with chronic renal failure on haemodialysis had serum pro-gastrin-releasing peptide concentrations greater than 46 ng/l. The highest serum pro-gastrin-releasing peptide levels in patients with chronic renal failure, before and after initiating haemodialysis were 183 and 290 ng/l respectively. Ten of 16 (63%) small-cell lung carcinoma patients had serum pro-gastrin-releasing peptide concentrations greater than 290 ng/l, the highest level in haemodialysed patients. Serum pro-gastrin-releasing peptide concentrations were also elevated in patients with chronic glomerulonephritis or diabetes mellitus when their serum creatinine concentrations were greater than 120 micromol/l. And, there was a significant correlation, y=23.5+0.15x(n=22, r=0.82, P<0.001),between serum pro-gastrin-releasing peptide (y, in ng/l) and serum creatine (x in micromol/l) concentrations in those patients with renal dysfunction. The correlation between serum pro-gastrin-releasing peptide and serum urea nitrogen concentrations was likewise significant. CONCLUSIONS:
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Authors | K Kamata, M Uchida, Y Takeuchi, E Takahashi, N Sato, Y Miyake, M Okubo, T Kodama, K Yamaguchi |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 11
Issue 7
Pg. 1267-70
(Jul 1996)
ISSN: 0931-0509 [Print] England |
PMID | 8672021
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Peptides
- Protein Precursors
- Gastrin-Releasing Peptide
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Topics |
- Adult
- Arthritis, Rheumatoid
(blood)
- Biomarkers, Tumor
(blood)
- Carcinoma, Small Cell
(blood)
- Diabetes Mellitus
(blood)
- Enzyme-Linked Immunosorbent Assay
(methods)
- Female
- Gastrin-Releasing Peptide
- Glomerulonephritis
(blood)
- Humans
- Kidney Diseases
(blood)
- Kidney Failure, Chronic
(blood)
- Lung Neoplasms
(blood)
- Lupus Erythematosus, Systemic
(blood)
- Male
- Middle Aged
- Peptides
(blood)
- Protein Precursors
(blood)
- Reference Values
- Reproducibility of Results
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