Changes in gene expression of cholecystokinin-A receptor after induction of pancreatitis by pancreatic duct occlusion in rats.

Abstract

Serial changes in the levels of cholecystokinin (CCK)-A receptor mRNA in the pancreas after pancreatic duct occlusion were examined in rats. CCK-A receptor mRNA level was determined by Northern blot analysis with a rat CCK-A-receptor cDNA probe. The level of CCK-A receptor mRNA first decreased, reaching the lowest level 7 days after occlusion, and then began to increase. On day 14, it had completely recovered to the control level and it remained at that level until 28 days after occlusion.

• Authors: K Miyasaka, A Funakoshi
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 30 Issue 5 Pg. 683-5 (Oct 1995) ISSN: 0944-1174 [Print] Japan
• PMID: 8574345 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• Receptor, Cholecystokinin A
• Receptors, Cholecystokinin

Topics

• Animals
• Disease Models, Animal
• Gene Expression (physiology)
• Male
• Pancreatic Ducts (surgery)
• Pancreatitis (metabolism)
• RNA, Messenger (metabolism)
• Rats
• Rats, Wistar
• Receptor, Cholecystokinin A
• Receptors, Cholecystokinin (genetics, metabolism)