The short-term course of sea water wet
near-drowning was studied in anesthetized rabbits breathing spontaneously. Therapeutic trials were incorporated using warm
n-butyl alcohol vapor both in inspired air and in inspired
oxygen. The purpose was to determine if
butyl alcohol vapor might alleviate the
hypoxemia of sea water aspiration, possibly by a defoaming action on the fine foam bubbles of alveolar origin in the lung
edema even without tracheal foam being present. The findings from 20 rabbits without overt tracheal foam, that had aspirated 2.05 mL/kg of sea water and were placed 10-minutes postaspirationally into four different inhalational treatment groups, showed remarkable differences. Warm
butyl alcohol vapor made by humidification of 7.5%
solution at 31 degrees C alleviated the
hypoxemia. With vapor treatment for 15 minutes, mean arterial
oxygen tension (PaO2) was not significantly changed in the
water vapor-air group, but increased significantly to 50.5 +/- 4.6, 70.0 +/- 8.9, and 146.7 +/- 40.7 mm Hg in the
butanol/
water vapor-air,
water vapor-
oxygen, and
butanol/
water vapor-
oxygen groups, respectively. With treatment for 30 minutes, mean PaO2 increased to 248.3 +/- 38.0 mm Hg with
butanol/
water vapor-
oxygen inhalations, but only to 91.2 +/- 9.8 mm Hg with 100%
water vapor-
oxygen inhalations. Thus, the inspired vapor of
butanol was much more effective in elevation of arterial blood
oxygen pressures when combined with
oxygen therapy over the values found when 100%
water vapor-
oxygen treatments were given. Respiratory and
cardiac depressant effects from inspired
butanol were not evident.(ABSTRACT TRUNCATED AT 250 WORDS)