Abstract | BACKGROUND: The objective was to characterise the process and consequences of eosinophil activation and lysis in patients with chronic eosinophilic pneumonia and to compare them with those in patients with eosinophil pulmonary infiltrates from other causes. METHODS: RESULTS: In the four patients with chronic eosinophilic pneumonia, ultrastructural studies demonstrated numerous lysed eosinophils. Further, three released eosinophil proteins were detected in distinct cytoplasmic structures in alveolar macrophages. These features were not found in the four patients with eosinophilic pulmonary infiltrates from other causes. CONCLUSION: Eosinophils in chronic eosinophilic pneumonia show signs of activation with release of eosinophil proteins. The appearance of three of these eosinophil proteins in different macrophage compartments suggests that macrophage uptake, with or without intracellular transport of released eosinophil proteins, involves separate mechanisms. This interaction does not lead to macrophage lysis, however, and one or more of these eosinophil proteins might directly affect macrophage function.
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Authors | A Janin, G Torpier, P Courtin, M Capron, L Prin, A B Tonnel, P Y Hatron, B Gosselin |
Journal | Thorax
(Thorax)
Vol. 48
Issue 1
Pg. 57-62
(Jan 1993)
ISSN: 0040-6376 [Print] England |
PMID | 8434356
(Publication Type: Journal Article)
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Chemical References |
- Blood Proteins
- Eosinophil Granule Proteins
- Glycoproteins
- Ribonucleases
- Lysophospholipase
- lysolecithin acylhydrolase
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Topics |
- Adult
- Blood Proteins
(analysis)
- Bronchoalveolar Lavage Fluid
(chemistry, cytology)
- Chronic Disease
- Eosinophil Granule Proteins
- Eosinophils
(metabolism)
- Female
- Glycoproteins
(analysis)
- Humans
- Immunohistochemistry
- Lysophospholipase
- Macrophages, Alveolar
(metabolism)
- Male
- Microscopy, Electron
- Middle Aged
- Pulmonary Alveoli
(metabolism)
- Pulmonary Eosinophilia
(metabolism)
- Ribonucleases
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