Spontaneous resolution of acquired factor X deficiency in amyloidosis.

Abstract

We describe the case of a 51-year-old man with systemic amyloidosis in whom factor X activity was initially 6% of the normal. Amyloidosis was responsible for congestive heart failure and a nephrotic syndrome but there was no bleeding diathesis. A 12-month trial of melphalan and prednisone failed to improve cardiac and renal dysfunction; factor X levels remained low. Eighteen months after this treatment was stopped, factor X spontaneously normalized although renal insufficiency persisted. We suggest that the possibility of a spontaneous factor X recovery must be considered when evaluating efficacy of therapeutic agents in amyloidosis.

• Authors: A le Quellec, A Sotto, A J Ciurana
• Journal: Journal of internal medicine (J Intern Med) Vol. 234 Issue 3 Pg. 329-30 (Sep 1993) ISSN: 0954-6820 [Print] England
• PMID: 8354985 (Publication Type: Case Reports, Journal Article)

Topics

• Amyloidosis (complications)
• Factor X Deficiency (blood, complications)
• Humans
• Male
• Middle Aged
• Remission, Spontaneous