[In vitro IL-6- and immunoglobulin-production in patients with variable immunodeficiency syndrome (CVID)].

Abstract

In vitro immunoglobulin and IL-6 synthesis were investigated in patients with CVID and healthy controls. The IL-6 production was increased in CVID patients. However, after calibration to equal monocyte counts in the mononuclear cell population the difference between patients and controls was no longer significant. The immunoglobulin production in CVID was decreased but no correlation between immunoglobulin and IL-6 production was found. From these results we suggest that monocyte activation might be of importance in terms of secondary organ lesions frequently occurring in CVID patients.

• Authors: B F vd Heyden-Rynsch, C Diener, H Vogelsang, L Jäger
• Journal: Immunitat und Infektion (Immun Infekt) Vol. 21 Suppl 1 Pg. 43-4 (Apr 1993) Germany
• Vernacular Title: In vitro IL-6- und Immunglobulin-produktion bei Patienten mit variablem Immundefektsyndrom (CVID).
• PMID: 8344691 (Publication Type: English Abstract, Journal Article)

Chemical References

• Immunoglobulins
• Interleukin-6

Topics

• Cells, Cultured
• Common Variable Immunodeficiency (immunology)
• Humans
• Immunoglobulins (biosynthesis)
• In Vitro Techniques
• Interleukin-6 (biosynthesis)