Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 1. 6,11-Dihydro-11-oxodibenz]b,e]oxepin-2-acetic acids.

Abstract

A series of 6,11-dihydrodibenz[b,e]oxepin-2-acetic acids has been evaluated for both antiinflammatory and analgetic activity in the carrageenan paw edema and phenylquinone writhing assays. The requirements for optimal activity in this series appear rather specific: (a) an unsubstituted 6,11-dihydrodibenz[b,e]oxepin nucleus and (b) a carbonyl group in the 11 position. One derivative, 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid (11), has been selected for further study.

• Authors: D E Aultz, G C Helsley, D Hoffman, A R McFadden
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 20 Issue 1 Pg. 66-70 (Jan 1977) ISSN: 0022-2623 [Print] United States
• PMID: 833828 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Dibenzoxepins

Topics

• Animals
• Anti-Inflammatory Agents (chemical synthesis, pharmacology)
• Arthritis (prevention & control)
• Dibenzoxepins (chemical synthesis, pharmacology)
• Drug Evaluation, Preclinical
• Edema (prevention & control)
• Mice
• Rats
• Structure-Activity Relationship