[The effect of kobazol and atsizol on the proliferation of mononuclear cells].

Abstract

The authors studied the new imidazole-containing drugs cobazole and acizole for their effects on the proliferation of mononuclear cells from donors and patients with rheumatic arthritis. Acizole was found to produce no effects on mononuclear cell proliferation, whereas cobazole inhibited only the increased spontaneous proliferation of mononuclear cells in patients with rheumatic arthritis, which was due to a higher activity of nonspecific T-suppressor lymphocytes.

• Authors: V S Shirinskiĭ, E A Zhuk, E S Domnina, L A Baĭkalova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1993 Sep-Oct Vol. 56 Issue 5 Pg. 33-5 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie kobazola i atsizola na proliferatsiiu mononuklearnykh kletok.
• PMID: 8312806 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Imidazoles
• Mitogens
• Organometallic Compounds
• kobazol
• atsizol
• Cobalt
• Zinc

Topics

• Adjuvants, Immunologic (pharmacology)
• Arthritis, Rheumatoid (blood)
• Cell Division (drug effects)
• Cells, Cultured (cytology, drug effects)
• Cobalt (pharmacology)
• Depression, Chemical
• Dose-Response Relationship, Drug
• Humans
• Imidazoles (pharmacology)
• Leukocytes, Mononuclear (cytology, drug effects)
• Mitogens (pharmacology)
• Organometallic Compounds (pharmacology)
• T-Lymphocytes, Regulatory (cytology, drug effects)
• Zinc (pharmacology)