Abstract |
Multimeric complexes of synaptic vesicle and terminal membrane proteins are important components of the neurotransmitter release mechanism. The csp gene of Drosophila encodes proteins homologous to synaptic vesicle proteins in Torpedo. Monoclonal antibodies demonstrate different distributions of isoforms at distinct subsets of terminals. Deletion of the csp gene in Drosophila causes a temperature-sensitive block of synaptic transmission, followed by paralysis and premature death.
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Authors | K E Zinsmaier, K K Eberle, E Buchner, N Walter, S Benzer |
Journal | Science (New York, N.Y.)
(Science)
Vol. 263
Issue 5149
Pg. 977-80
(Feb 18 1994)
ISSN: 0036-8075 [Print] United States |
PMID | 8310297
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Membrane Proteins
- Nerve Tissue Proteins
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Topics |
- Animals
- Drosophila melanogaster
(embryology, genetics, physiology)
- Electroretinography
- Gene Deletion
- Genes, Insect
- Genes, Lethal
- Genetic Complementation Test
- Membrane Proteins
(analysis, genetics, physiology)
- Mutagenesis, Site-Directed
- Nerve Tissue Proteins
(analysis, genetics, physiology)
- Phenotype
- Photoreceptor Cells, Invertebrate
(physiology)
- Presynaptic Terminals
(chemistry, physiology)
- Synaptic Transmission
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