Platelet aggregation and adhesiveness in classical factor X deficiency and in the abnormal factor X (factor X Friuli) coagulation disorder.

Abstract

Platelet aggregation to common inductors and to Ristocetin, Thrombofax and Ionophore is normal in congenital factor X deficiency and in factor X Friuli coagulation disorders. Washed normal platelets resuspended in the patient's plasma and in adsorbed normal plasma showed a normal aggregation. On the contrary, normal platelets resuspended in normal serum failed to aggregate. These studies indicate that factor X plays no role in normal platelet aggregation.

• Authors: A Girolami, F Fabris, R Peruffo, P Coser
• Journal: Acta haematologica (Acta Haematol) Vol. 56 Issue 5 Pg. 307-13 ( 1976) ISSN: 0001-5792 [Print] Switzerland
• PMID: 826088 (Publication Type: Journal Article)

Chemical References

• Ristocetin
• Calcimycin
• Adenosine Diphosphate
• Collagen
• Thromboplastin
• Epinephrine

Topics

• Adenosine Diphosphate (pharmacology)
• Blood Coagulation Disorders (blood)
• Calcimycin (pharmacology)
• Collagen (pharmacology)
• Epinephrine (pharmacology)
• Factor X Deficiency (blood)
• Humans
• Hypoprothrombinemias (blood)
• Platelet Adhesiveness (drug effects)
• Platelet Aggregation (drug effects)
• Ristocetin (pharmacology)
• Thromboplastin (pharmacology)