Ionophores

Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes.

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Networked: 906 relevant articles (23 outcomes, 65 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Antoszczak, Michał: 11 articles (01/2022 - 10/2015)
2.	Huczyński, Adam: 10 articles (01/2022 - 10/2015)
3.	Lang, Florian: 8 articles (01/2018 - 01/2013)
4.	Jiang, Shanxiang: 7 articles (10/2020 - 01/2014)
5.	Chen, Xin: 6 articles (07/2021 - 01/2014)
6.	Page, Stephen W: 6 articles (09/2020 - 01/2015)
7.	Trott, Darren J: 6 articles (09/2020 - 01/2015)
8.	Volitakis, Irene: 5 articles (10/2020 - 01/2014)
9.	Hickey, Elizabeth E: 5 articles (09/2020 - 04/2018)
10.	Gao, Xiuge: 4 articles (10/2020 - 02/2018)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2023 - "However, existing Cu ionophores are small molecules with a short blood half-life making it hard to transport enough Cu into cancer cells. " 01/15/2023 - "Furthermore, in recent years ionophores were candidates for reprofiling as antibacterial and anti-cancer drugs. " 01/01/2022 - "Here, Cu ionophores are discussed with a focus on selectivity towards cancer cells and on the mechanisms responsible for this selectivity. " 12/20/2021 - "The ionophore suppressed tumor proliferation in vitro and in vivo based on the pro-apoptotic activity and immunogenicity." 10/13/2021 - "In addition, their ability to disrupt cellular homeostasis and to alter lysosomal pH endow ionophores as promising candidates for cancer treatment. "
2.	Hypoxia (Hypoxemia) 01/01/2017 - "Cells were either treated with Ca2+ ionophores or subjected to hypoxia followed by reoxygenation. " 07/01/1999 - "In contrast to hypoxia, Ca2+ ionophore and Fe each induced significant PL losses (6 to 15%) despite minimal FFA accumulation or cell death (26 to 27% LDH release). " 10/30/1992 - "We conclude that hypoxia and ionophore increase PAF synthesis and release from endothelial cells." 10/30/1992 - "(4) Bioactive PAF was released into media and hypoxia and ionophore synergistically increased PAF release. " 03/01/1991 - "Subsequent addition of Ca ionophores increased Caf to 300-500 nM in the first 2 min and to greater than 1 microM after 15 min. In individual experiments, anoxia produced similar responses to those of chemical hypoxia, eliciting no average significant change in Caf, despite clear evidence for impaired respiration and plasma membrane damage after 40 min of anoxia. "
3.	Coccidiosis 05/01/2000 - "Although ionophores have been used widely in the beef industry for improved feed efficiency and control of coccidiosis, there has been limited use by the dairy industry. " 01/15/2023 - "For many years, ionophores have been used to control coccidiosis in poultry. " 11/01/2022 - "Coccidiosis is an endemic protozoal disease of chickens normally controlled by ionophores. " 12/01/2021 - "Impact assessment of the reduction or removal of ionophores used for controlling coccidiosis in the UK broiler industry." 01/01/2020 - "Ionophore compounds active against Eimeria species are widely used in intensive broiler systems and have formed the backbone of coccidiosis control for almost 50 years. "
4.	Body Weight (Weight, Body) 11/01/1987 - "Inclusion of either ionophore into the ration had no effect on final body weight, but improved feed conversion (P less than .05). " 10/27/2020 - "Likewise, another chemically distinct copper ionophore H2(gtsm), administered daily (oral gavage), also augmented hepatic copper and moderated mouse body weight. " 03/01/2019 - "In experiments of coronary blockade and reperfusion carried out in rat heart, it was found that when administered from 5 to 30 minutes prior to the induction of coronary blockade, at a concentration of 2 mg/kg of body weight, the ionophore immediately, simultaneously, and completely interrupts the blood pressure decay, cardiac frequency increase, electrical ventricular tachycardia and fibrillation, as well as the fall of mitochondrial oxidative phosphorylation and decay of mitochondrial oxygen uptake provoked by the induced myocardial injury. " 01/01/2006 - "To examine the effect of ionophore supplementation on fecal shedding of Escherichia coli O157:H7 and Salmonella, crossbred beef calves (n=113; mean body weight [BW], 243 kg) were fed a mineral supplement with ionophore (1.76 g lasalocid/kg) for 61 days (d). " 01/01/1989 - "Male lambs, crossbred Merino × Ille de France, were fed a diet supplemented with 31 mg monensin or 32 mg lasalocid per kg of feed dry matter from an initial body weight of 23·6-23·9 kg to the slaughter weight of approximately 40 kg. Carcass traits and meat quality were evaluated after slaughter; the values obtained were compared with those of the control group fed the same diet without the ionophore supplement. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "In the present study, we explored the antiangiogenic and anticancer efficacy of the polyether ionophore SAL in the breast cancer model. " 02/15/2021 - "The polyether ionophore salinomycin (SAL) has been found to selectively target breast cancer cells, including those with stem-like phenotype. " 10/01/2017 - "Salinomycin (SAL), a monocarboxylic polyether ionophore is known for selectively targeting breast cancer stem cells. " 01/01/2017 - "Accordingly, we investigated whether salinomycin, a monocarboxylic ionophore, could induce apoptosis in aggressive breast cancer cells or not, as well as its underlying mechanism. " 11/08/2016 - "Here, we show that low-dose salinomycin, a coccidiostat ionophore previously identified in a breast cancer screen, has anti-leukemic efficacy. "

Related Drugs and Biologics

1.	Monensin (Coban)
2.	salinomycin
3.	Lasalocid
4.	Zinc
5.	Anti-Bacterial Agents (Antibiotics)
6.	Copper
7.	Calcium
8.	Luminescent Proteins
9.	Calcimycin (A23187)
10.	Clioquinol (Vioform)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Immunotherapy
4.	Lenses
5.	Therapeutics