[The use of a complex cobalt compound as a cyanide antidote].

Abstract

The medical effect of the cobalt (III) complex compound [Co(DH)2(H2O)2]Cl poisoning by potassium cyanide has been experimentally found. The poisoning has been caused by intravenous potassium cyanide, 1 mg/kg. The aqueous solution of the complex was added the same to cyanide in doses of 40 and 80 mg/kg. The poison and antidote effects were controlled by bioelectrical tests of the brain and heart. The advantage of the preparation is its direct interaction with cyanide and significantly lower doses as compared with the well-known anticyanide antidotes.

• Authors: B A Bovykin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1994 Mar-Apr Vol. 57 Issue 2 Pg. 57-60 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Primenenie kompleksnogo soedineniia kobal'ta v kachestve protivotsianidnogo antidota.
• PMID: 8205053 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidotes
• Solutions
• Cobalt
• Potassium Cyanide

Topics

• Animals
• Antidotes (therapeutic use, toxicity)
• Cats
• Cobalt (therapeutic use, toxicity)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Electrocardiography (drug effects)
• Electroencephalography (drug effects)
• Female
• Male
• Mice
• Poisoning (drug therapy, physiopathology)
• Potassium Cyanide (poisoning)
• Solutions