Poisons

Substances which, when ingested, inhaled, or absorbed, or when applied to, injected into, or developed within the body in relatively small amounts may, by their chemical action, cause damage to structure or disturbance of function. (From Dorland, 27th ed)

Also Known As:

Networked: 2935 relevant articles (65 outcomes, 239 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Buckley, Nicholas A: 17 articles (04/2022 - 01/2002)
2.	Isbister, Geoffrey K: 12 articles (04/2022 - 12/2002)
3.	Wananukul, Winai: 12 articles (02/2022 - 06/2007)
4.	de Haro, Luc: 12 articles (01/2022 - 01/2003)
5.	Spiller, Henry A: 12 articles (01/2021 - 01/2003)
6.	Osheroff, Neil: 12 articles (11/2020 - 06/2004)
7.	Forrester, Mathias B: 12 articles (01/2018 - 10/2003)
8.	Dawson, Andrew H: 11 articles (02/2022 - 01/2002)
9.	Austin, Caroline A: 11 articles (01/2022 - 06/2004)
10.	Cairns, Rose: 11 articles (01/2022 - 03/2016)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2017 - "These results suggest that blockade of NRF2 signaling may enhance therapeutic efficacy and reduce the survival of Top II poison-refractory tumors in clinical." 02/01/2010 - "Microtubule poisons are widely used in cancer treatment, but the factors determining the relative efficacy of different drugs in this class remain obscure. " 07/14/2010 - "Our data indicates that the previously observed long-term efficacy of SB-T-1214 against drug resistant colon tumors in vivo may be explained by the down-regulation of multiple stem cell-related genes in the tumorigenic cell population, in addition to its known efficacy as a mitotic poison against proliferating cancer cells." 01/10/2007 - "Finally, these results raise the possibility that RKIP status in tumors could influence the efficacy of treatments such as poisons that stimulate the Aurora B-dependent spindle assembly checkpoint." 01/01/2022 - "An important step in efficacy testing is the in vivo study, most often using immunodeficient murine models into which both the poison and the cure are injected; namely a human cancer cell line and genetically modified human T cells. "
2.	Poisoning 03/01/2003 - "Recognizing a Toxidrome (constellation of the signs and symptoms seen with the ingestion of a particular poison) is particularly very helpful when the child presents with an unknown poisoning. " 11/15/2021 - "Overall, there was a significant reduction in the annual population-adjusted poison exposures in children (annual percentage change = -2.54%, 95% CI = -3.94% to -1.15%, p < 0.01), but not in poisoning-related fatalities. " 01/01/2014 - "Fatal poisoning data can reveal trends in the poisons encountered, which can help guide prescribing practices and product safety and other legislation, and more recently has helped to monitor the use of emerging drugs of abuse ( ‘ legal highs ’ ). " 09/01/2010 - "Greater national efforts should be directed towards improved poison prevention, rational management of pediatric poisoning, and creating a national poisoning registry." 06/01/2016 - "A number of benefits might result from such a poisons centre network hub, including: (1) Improved cooperation between countries on poisoning problems; (2) Harmonisation and strengthening of research and surveillance; (3) Common standards and best practices e.g. "
3.	Bites and Stings (Sting) 01/01/2021 - "Scorpions are among the most popular research objects within Arachnida and there is an impressive body of knowledge about their biology, distribution, morphology, etc. Although the poison sting has gained a lot of attention due to its potential lethal effects to humans, hitherto, there has been no comparative morphological study on the metasoma, the body part that delivers the poisonous injection. " 01/01/2018 - "This study describes M opercularis caterpillar stings reported to Texas poison centers. " 01/01/2009 - "The study sample consists of all cases of bites and stings by exotic pets that were registered at four poisons European poisons centers. " 04/01/2006 - "This study examined the relationship between selected factors and all human exposures involving jellyfish stings reported to Texas poison centers. " 10/01/2003 - "This study used data from human exposure calls to poison centers in Texas to compare the epidemioloy of bites from these 2 spiders. "
4.	Breast Neoplasms (Breast Cancer) 10/01/2023 - "Here, we show in metastatic breast cancer and relevant human cellular models that this mechanism is conserved among clinically useful microtubule poisons. " 01/01/2020 - "These results suggest that DHA increases the effect of T-DM1 as poison for microtubules and supports the clinical development of the combination of DHA and T-DM1 for the treatment of aggressive HER2-overexpressing breast cancer." 01/01/2019 - "Several active compounds present in foods, poisons, drugs, and industrial chemicals may as a result of epigenetic mechanisms increase or decrease the risk of breast cancer. " 10/01/2015 - "Induction of autophagy or inhibition of AMPK or PFKFB3 results in enhanced cell death in mitosis and improves the anti-tumoral efficiency of microtubule poisons in breast cancer cells. " 03/01/2007 - ""Yudu Weiqing" (vestigial poison) is the main pathogenesis of breast cancer after operation. "
5.	Snake Bites (Snake Bite) 11/04/1892 - "NEW TREATMENT FOR SNAKE-BITE AND OTHER POISONS." 06/01/1975 - ""Doctor Caesar" and his cure for poisons and rattle-snake bites." 06/01/2011 - "This study was based on a retrospective descriptive analysis of all cases of snakebite recorded at the Poison Control and Pharmacovigilance Center of Morocco from 1980 to 2008. " 09/01/2010 - "The study used a retrospective review of all snakebites to humans reported to the National Poison Center Database System from 2000 to 2007. " 01/01/2010 - "This study retrospectively analyzed all human coral snakebites voluntarily reported by the public and/or health care professionals to poison centers that were subsequently published in the Annual Reports of the American Association of Poison Control Centers (AAPCC) from 1983 through 2007. "

Related Drugs and Biologics

1.	Type II DNA Topoisomerases (Topoisomerase II)
2.	Type I DNA Topoisomerases (Topoisomerase I)
3.	Poisons
4.	Etoposide (VP 16)
5.	trioctyl phosphine oxide (TOPO)
6.	Camptothecin
7.	Topotecan (Hycamtin)
8.	Antidotes
9.	Insecticides
10.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Therapeutics
2.	Hemoperfusion
3.	Fluid Therapy (Oral Rehydration Therapy)
4.	Castration
5.	Assisted Circulation