[An intranasal method of revaccination against mumps].

Abstract

The effectiveness of revaccination against mumps was studied using different routes for administration of a live mumps vaccine from L-3 strain. Poor reactogenicity of the vaccine was observed after intranasal administration. The highest rise in titres of virus-neutralizing antibody was demonstrated in volunteers given the vaccine by the intranasal route. Revaccination of adults by both intranasal and subcutaneous routes induced production of antigen-specific memory cells. The results of the study attest to the usefulness of the intranasal route of vaccine administration in revaccinations against epidemic parotitis.

• Authors: V P Krasnova, N V Iuminova, V A Liashenko
• Journal: Voprosy virusologii (Vopr Virusol) 1994 Jan-Feb Vol. 39 Issue 1 Pg. 24-6 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Intranazal'nyĭ sposob revaktsinatsii protiv épidemicheskogo parotita.
• PMID: 8160444 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antibodies, Viral
• Mumps Vaccine

Topics

• Administration, Intranasal
• Adolescent
• Adult
• Antibodies, Viral (blood)
• Humans
• Immunization, Secondary (methods)
• Injections, Subcutaneous
• Lymphocyte Activation
• Mumps (immunology, prevention & control)
• Mumps Vaccine (administration & dosage, adverse effects)
• Mumps virus (immunology)
• Time Factors