Interactions between U-50,488H and sigma receptor antagonists: EEG, EEG power spectral and behavioral correlates.

Abstract

I.v. administration of U-50,488H after i.v. saline pretreatment produced occasional high-voltage EEG slow-wave bursts that were associated with relatively small increases in spectral power in the 2.5-7.5 Hz band as a spectral peak and with behavioral incidents of sedation, ataxia, ptosis, straub tail, hunching of the back, and backing-up. After pretreatment with the sigma antagonists rimcazole and DuPont Merck S-7389-4, U-50,488H administration produced significantly larger increases in absolute EEG spectral power, both over the 1-50 Hz range and in the 2.5-5.0 and 5.0-7.5 Hz bands, than after saline pretreatment; rimcazole pretreatment eliminated U-50,488H-induced incidents of ataxia, ptosis, hunching of the back and backing-up. In summary, effects of U-50,488H on EEG, EEG power spectra and behavior may reflect interactions between kappa opioid and sigma (non-opioid) receptor-effector systems.

• Authors: G A Young, G M Hudson, H Stamidis, G F Steinfels
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 231 Issue 3 Pg. 473-6 (Feb 16 1993) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8095467 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antihypertensive Agents
• Antipsychotic Agents
• Carbazoles
• Pyrrolidines
• Receptors, sigma
• 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
• rimcazole

Topics

• 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
• Animals
• Antihypertensive Agents (pharmacology)
• Antipsychotic Agents (pharmacology)
• Behavior, Animal (drug effects)
• Carbazoles (pharmacology)
• Drug Interactions
• Electroencephalography (drug effects)
• Female
• Injections, Intravenous
• Pyrrolidines (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Receptors, sigma (antagonists & inhibitors)