Antiemetic effects of serotonergic 5-HT1A-receptor agonists in Suncus murinus.

Abstract

The antiemetic effects of six serotonergic 5-HT1A-receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetrarin (8-OH-DPAT), 4-(4-[4-(2-pyrimidinyl)piperazin-1-yl]butyl)-2,3,4,5- tetrahydro-1,4-benzoxazepine-3,5-dione (SUN8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in Suncus murinus. Subcutaneous injection of all six agonists completely and dose-dependently suppressed motion-induced emesis. Pretreatment with 8-OH-DPAT or SUN8399 dose-dependently inhibited emesis elicited by nicotine (4.0 mg/kg, s.c.), veratrine (0.7 mg/kg, s.c.), cisplatin (20 mg/kg, i.p.) and copper sulfate (40 mg/kg, p.o.). These results suggest that serotonergic 5-HT1A-receptor agonists are effective as anti-motion sickness drugs, and these drugs may block a common mechanism(s) for the emetic reflex of the suncus because the antiemetic effects of the 5-HT1A-receptor agonists were exerted irrespective of the stimulus.

• Authors: F Okada, Y Torii, H Saito, N Matsuki
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 64 Issue 2 Pg. 109-14 (Feb 1994) ISSN: 0021-5198 [Print] Japan
• PMID: 8028227 (Publication Type: Journal Article)

Chemical References

• Antiemetics
• Oxazepines
• Serotonin Receptor Agonists
• SUN 8399
• 8-Hydroxy-2-(di-n-propylamino)tetralin
• Buspirone

Topics

• 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology)
• Animals
• Antiemetics (pharmacology)
• Buspirone (pharmacology)
• Dose-Response Relationship, Drug
• Male
• Motion Sickness (prevention & control)
• Oxazepines (pharmacology)
• Serotonin Receptor Agonists (pharmacology)
• Shrews (physiology)
• Vomiting (chemically induced, prevention & control)