PS-990, a novel neuritogenic compound from Acremonium sp.

Abstract	A novel compound, PS-990, which induces differentiation of neuroblastoma cells, was isolated from the culture broth of a fungus, Acremonium sp. KY12702. PS-990 inhibited brain calcium calmodulin-dependent cyclic nucleotide phosphodiesterase with an IC50 value of 3 micrograms/ml, and markedly induced neurite extension of mouse neuroblastoma, Neuro2A, at concentrations ranging from 10 to 30 micrograms ml.
Authors	S Toki, K Ando, M Yoshida, Y Matsuda
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 47 Issue 11 Pg. 1175-81 (Nov 1994) ISSN: 0021-8820 [Print] England
PMID	8002379 (Publication Type: Journal Article)
Chemical References	Hydroxybenzoates Phosphodiesterase Inhibitors PS 990
Topics	Acremonium (classification, metabolism) Animals Cattle Fermentation Hydroxybenzoates (isolation & purification, pharmacology) Mice Neurites (drug effects) Neuroblastoma (pathology) Phosphodiesterase Inhibitors (isolation & purification, pharmacology) Tumor Cells, Cultured

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