Inhibitory effect of vapiprost on contractile responses of isolated dog renal arteries to thromboxane A2 analogue, U46619.

Abstract

1. Cumulative administrations of U46619, a thromboxane A2 analogue, and prostaglandin (PG) F2 alpha produced concentration-dependent contractions of isolated dog renal arterial preparations, which were significantly and concentration-dependently inhibited by vapiprost. 2. A bolus administration of U46619 or PGF2 alpha produced sustained contracture of these preparations, which was concentration-dependently relaxed by cumulative vapiprost. 3. Results indicate that vapiprost inhibits U46619- and PGF2 alpha-induced dog renal arterial contractions through antagonism for so-called TP receptors.

• Authors: M Sakanashi, T Matsuzaki, K Noguchi, J Nakasone, T Itomine, M Uza, F Toyama, M Higuchi
• Journal: General pharmacology (Gen Pharmacol) Vol. 25 Issue 4 Pg. 617-22 (Jul 1994) ISSN: 0306-3623 [Print] England
• PMID: 7958719 (Publication Type: Journal Article)

Chemical References

• Biphenyl Compounds
• Heptanoic Acids
• Prostaglandin Endoperoxides, Synthetic
• Receptors, Thromboxane
• Vasoconstrictor Agents
• Thromboxane A2
• 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
• Dinoprost
• vapiprost

Topics

• 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
• Animals
• Biphenyl Compounds (pharmacology)
• Dinoprost (pharmacology)
• Dogs
• Dose-Response Relationship, Drug
• Female
• Heptanoic Acids (pharmacology)
• In Vitro Techniques
• Male
• Prostaglandin Endoperoxides, Synthetic (pharmacology)
• Receptors, Thromboxane (antagonists & inhibitors)
• Renal Artery (drug effects, physiology)
• Thromboxane A2 (analogs & derivatives, pharmacology)
• Vasoconstriction (drug effects)
• Vasoconstrictor Agents (pharmacology)